HI TG IN PREGNANCY Flashcards
What percentage increase is observed in serum total cholesterol during pregnancy?
75%
What are the mean values of total cholesterol and triglycerides during pregnancy?
- Total cholesterol: 317 mg/dL (8.21 mmol/L)
- Triglycerides: 300 mg/dL (3.39 mmol/L)
What happens to lipid levels after delivery?
Lipid levels gradually return to prepartum levels.
What risks do elevated triglyceride levels pose during pregnancy?
May lead to pancreatitis, posing risks to both mother and fetus.
How can gestational diabetes affect triglyceride levels?
Can increase the risk of severe hypertriglyceridemia.
What should be done with lipid-altering drugs before conception?
They should generally be stopped.
Why are statins contraindicated in pregnancy?
Due to teratogenicity.
What is the recommendation regarding medication use during pregnancy?
Medications should ideally be avoided, especially in the first trimester.
What medication was continued during the first trimester despite limited safety data?
Fenofibrate.
What is the effectiveness of omega-3 fatty acids in treating triglyceride levels during pregnancy?
Not very effective; might be preferred in the first trimester.
Which medication is considered more potent for managing triglyceride levels in the second and third trimesters?
Fenofibrate.
How does nicotinic acid compare to fenofibrate in reducing triglyceride levels?
Less effective than fenofibrate.
What is the standard initial treatment for hypertriglyceridemia and pancreatitis in pregnancy?
- Fasting
- Fluid administration
- Pain control
What can be administered if hyperglycemia is present in a pregnant patient with hypertriglyceridemia?
Intravenous insulin.
Name some other treatments for hypertriglyceridemia and pancreatitis in pregnancy.
- Intravenous heparin
- Plasma exchange
- Lipoprotein apheresis
- Possibly cesarean delivery if pregnancy is sufficiently advanced.
