LABORATORY EVALUATION OF FIBRINOLYSIS

Question 1

In whole blood clot lysis time, the clot should remain intact for 48 hours at 37 Degrees Celsius, dissolution of the clot before 48 hours is indicative of?

Answer 1

Excessive systemic fibrinolysis

Question 2

The principle of this test is that when plasma is diluted with water and acidified, proteins are precipitated.

Answer 2

Euglobulin Lysis Time

Question 3

Reference range of Euglobulin lysis time

Answer 3

Lysis in less than 2 hours is indicative of increased fibrinolytic activity

Question 3

A test for secondary (smaller) fibrin degradation products

Answer 3

Protamine sulfate gelation test

Question 4

Reference range/value of protamine sulfate fibrin degradation product

Answer 4

Normally, no gel formation is seen

Question 5

Less sensitive but more specific than the protamine sulfate test in detecting soluble fibrin monomers and polymers in plasma

Answer 5

Ethanol Gelation Test (EGT)

Question 6

Reference range of EGT

Answer 6

there should be no gel formation under normal conditions

Question 7

Measures a specific fragment arising from the degradation of fibrin (D-dimer); measures fibrinolysis and not fibrinogenolysis

Answer 7

LATEX D-DIMER ASSAY

Question 8

Latex D-dimer assay is already positive after ___ hours of DIC onset

Answer 8

4 hours

Question 9

D-dimer is positive in primary fibrinogenolysis

true or false

Answer 9

False

• In primary fibrinogenolysis, there is an increased activation of plasmin which results in fibrinogen being broken down (not fibrin clot). D-dimer is produced when fibrin clot is broken down.

Question 10

In primary fibrinogenolysis, Euglobulin clot lysis time is shortened

true or false

Answer 10

True

• the normal reference value of euglobulin lysis time is the precipitate should not lyse within 2 hours. In cases with Primary fibrinogenolysis, the precipitate lysis in less than 2 hours which is indicative of increased fibrinolytic activity

Question 11

An anticoagulant therapy that is used for monitoring APTT

Answer 11

Heparin therapy

Question 12

An anticoagulant therapy that is used for monitoring PT

Answer 12

Warfarin/Coumarin therapy

Question 13

Rat poison active ingredient:

Answer 13

Warfarin/coumarin

Question 14

PIVKA stand for?

Answer 14

Protein induced by Vitamin K absence