BLEEDING DISORDERS DUE TO VASCULAR DEFECTS

Question 1

A connective tissue disorder is characterized by hyperextensible joints and hyperplastic skin. The defect may lie in a peptidase enzyme deficiency that converts procollagen to collagen

Answer 1

Ehlers-Danlos Syndrome

Question 2

Connective tissue elastic fibers in small arteries are calcified and structurally abnormal. Subarachnoid and gastrointestinal bleeding are the most common cause of death

Answer 2

Pseudoxanthoma Elasticum

Question 3

Acquired disorder of dietary deficiency of vitamin C. (vitamin C deficiency)

Answer 3

Scurvy

Question 4

The aging process brings about the degeneration of collagen, elastin, and subcutaneous fat

Answer 4

Senile purpura

Question 5

Characterized by vascular malformations and surface skin lesions; The small blood vessels are focally disorganized and dilated throughout the body, their wall support is poor, and their ability to contract is diminished

Answer 5

Hereditary Hemorrhagic Telangiectasia

Question 6

A disorder associated with tumors composed of vessels that commonly swell and bleed at the surface

Answer 6

Congenital Hemangiomata (Kasabach-Meritt Syndrome)

Question 7

The large vessels may become atherosclerotic, and the capillary basement membrane may thicken, thus blocking the normal flow of blood; Most often affected are the glomerulus and retina

Answer 7

Diabetes mellitus

Question 8

It can involve and obstruct the function of many organs, including the vascular system, in which there is deposition of the fibrillar protein called amyloid

Answer 8

Amyloidosis

Question 9

Damage caused by autoimmune of infectious agents to the endothelial lining of the blood vessel may lead to hypercoagulation or hypocoagulation

Answer 9

Endothelial damage

Question 10

purpura associated with abdominal pain secondary to GIT hemorrhaging

Answer 10

HENOCH

Question 11

purpura associated with joint pain, especially in the knees and ankles

Answer 11

SCHONLEIN