HEMOGLOBINOPATHIES Flashcards
memorization
No Hb is produced; Hb insolubility results when deoxyhemoglobin is formed. Hb crystallizes, forming the classic sickle shape of the cell
Sickle cell disease (Hb SS)
In Sickle cell disease, there is approximately ___% Hb S and ___% Hb F
80% Hb S
20% Hb F
Defect is inherited from one parent only; Approximately 60% Hb A and 40% Hb S
Sickle cell trait (Hb AS)
No Hb A is produced; approximately 90% Hb C, 2% Hb A2, and 7% Hb F
Hb C disease (Hb CC)
Folded cells can be found in what condition?
Hb C disease
A double heterozygous condition where an abnormal sickle cell gene from one parent and abnormal C gene from the other parent is inherited; No Hb A is produced
Hb SC disease
Hb C crystals can be seen in Hb C disease only and not in Hb SC disease
true or false
False
Hb C crystal can be seen in both Hb C and SC disease
Hb SC crystals can be seen in both Hb C and Hb Sc disease
true or false
False
Hb SC crystal is exclusively produced in Hb SC disease
Hemoglobin S
____ amino acid of B chain; glutamate is replaced by _____
6th amino acid of B chain; glutamate is replaced by Valine
hemoglobin C
____ amino acid of B chain; glutamate is replaced by _____
6th amino acid of B chain; glutamate is replaced by Lysine
hemoglobin D
____ amino acid of B chain; glutamate is replaced by _____
121st amino acid of B chain; glutamate is replaced by Glysine
hemoglobin E
____ amino acid of B chain; glutamate is replaced by _____
26th amino acid of B chain; glutamate is replaced by Lysine
hemoglobin O
____ amino acid of B chain; glutamate is replaced by _____
121st amino acid of B chain; glutamate is replaced by Lysine
most anodal hemoglobin in cellulose acetate medium
Hb A
most anodal hemoglobin in citrate agar
Hb C
