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HEMATOLOGY (Topnotcher QT) > DISORDERS OF THROMBOSIS , HEMORRHAGIC DISORDERS > Flashcards

DISORDERS OF THROMBOSIS , HEMORRHAGIC DISORDERS Flashcards

memorization

1
Q

Principal inhibitor of thrombin is deficient

A

Antithrombin-III Deficiency

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2
Q

Proteins that inactivates factor Va and VIIIa

A

Protein C and S

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3
Q

A mutated form of FV which resists protein C and S inactivation

A

Factor V Leiden

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4
Q

An abnormal functional fibrinogen molecule is produced and is resistant to fibrinolysis

A

dysfibrinogenemia

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5
Q

abnormal platelet-vessel wall interaction; leads to clotting disease

A

Homocystinuria

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6
Q

Associated with thrombosis due to prostacyclin inhibition; prolonged APTT that does not correct with normal plasma substitution

A

Lupus anticoagulant

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7
Q

Factor XI deficiency (Hemophilia C) is also known as

A

Rosenthal Syndrome

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8
Q

More than half of the cases of hemophilia C have been described in

A

Ashkenazi Jews

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9
Q

Also known as Hemophilia A

A

Factor VIII:C Deficiencyh

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10
Q

What is the treatment for Hemophilia A?

A
  • Cryoprecipitate
  • FVIII Concentrate
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11
Q

Factor IX deficiency is also known as

A

Hemophilia B / Christmas Disease

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12
Q

Treatment for Factor IX deficiency

A
  • FFP
  • FIX concentrate
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13
Q

Defects of both Factor VIII:C and vWF

A

Von Willebrand Disease

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14
Q

Most frequently encountered hereditary coagulopathy

A

Von Willebrand Disease

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15
Q

Recommended initial workup for the diagnosis of Von Willebrand Disease

A

CBC, APTT, PT

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16
Q

Abnormal PT
Normal APTT
Normal TCT

A

Factor VII deficiency

17
Q

Abnormal APTT
Abnormal PT
Normal TCT

A
  • Factor X (stuart-prower factor) deficiency
  • Factor V Deficiency (Owren’s Disease)
  • Factor II (prothrombin) deficiency
    (All common pathway coag factors except Factor I)
18
Q

Abnormal APTT
Abnormal PT
Abnormal TCT

A

Factor I deficiency

19
Q

Clot dissolves in 5 M urea

A

Factor XIII Deficiency

20
Q

In hepatic disease, all coagulation factors except Factor III and VWF are decreased or increased?

A

Decrease

21
Q

A coagulation study procedure that is a sensitive test for liver function

A

PT (Prothrombin Time)

22
Q

Vitamin K is needed for what process for the PT group?

A

Gamma carboxylation

23
Q

Coagulation factors and platelets are destroyed leading to decreased coagulation proteins; consumptive coagulopathy

A

Disseminated Intravascular Coagulation (DIC)

24
Q

In Primary fibrinogenolysis, D-dimer is negative/decreased because

A

There is no clot formation, and fibrinogen is being broken down

25
Q

In DIC, are all coagulation tests prolonged or shortened?

A

prolonged

26
Q

Is D-dimer in DIC positive/increased or decreased/negative?

A

positive/increased

27
Q

Fibrinogen in DIC is

A. decreased
B. increased
C. decreased or normal
D. normal

A

C. decreased or normal

HEMATOLOGY (Topnotcher QT) (12 decks)

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