Lab: Toothpaste Flashcards
“powder for rubbing the teeth”
-Dentrificum
fricare
to rub
Dentis
tooth
-Agent used with a toothbrush to clean and polish the accessible
surfaces of the teeth
TOOTHPASTE
TOOTHPASTE forms
paste, powder, gel or liquid
T/F: Liquid form is different from mouthwash
True
Most important toothpaste form
paste
It is the preferred dosage vehicle for special therapeutic
and cosmetic agents due to its rheological properties in the
form of paste.
Paste form
It has
an occlusive property unlike powders or liquids that are
easily washed off by the saliva
Paste form
-Liquid form is not __________
abrasive
a biofilm or mass of bacteria that grows
on surfaces within the mouth.
Dental plaque
also known as
tartar
into dental calculus
TOOTHPASTE COMPOSITION
Abrasive
Foaming Agents
Flavoring Agents
Sweetening Agents
Humectant
Binder/Gelling Agent/Thickener
Coloring Agent
Preservative
Special Additives
-Particle size is largely below 0.4 mm in diameter
Abrasive
Titanium dioxide
Insoluble phosphate, Dicalcium phosphate (dihydrate and anhydrous), calcium phosphate
Sodium bicarbonate (baking soda)
Calcium carbonate (Precipitated chalk)
Hydrated silica
Silicon oxide, aluminum oxide, granular polyvinyl chloride
Abrasive
-Typical dentifrices which have significant consumer acceptability
are the toothpaste having a high content of____________ abrasive
such as: __________ and ________
water-insoluble;
● Dicalcium phosphate
● Sodium monofluorophosphate 0.2% in aqueous humectant
base
● sodium lauryl sulfate(SLS),
● sodium dodecylbenzene sulfonate,
● magnesium lauryl sulfate,
● sodium lauryl sulfoacetate,
● dioctyl sulfosuccinate, and
● sodium coconut monoglyceride sulfonate
Surfactant
peppermint, spearmint, wintergreen, cinnamon, mint,
thymol, menthol, clove oil, eucalyptol oil
flavoring agent
Leave a residual freshness and cooling sensation
Flavoring agent
-Sweetens the taste
-Non fermentable sugar
Sweetening agent
sodium saccharin (most widely used),
sorbitol, mannitol, glycerin, acesulfame,
aspartame
Sweetening agent
-Maintain moisture and consistency of paste by absorbing moisture
from air
HUMECTANT
-Provides creamy base which resists drying out
HUMECTANT
-Vehicle where other ingredients can be suspended or dissolved
HUMECTANT
5 to 35%of total vehicle
HUMECTANT
E.g. glycerol, 70% sorbitol, PG, PEG, mannitol
HUMECTANT
-Maintains the PASTY consistency of the preparation
BINDER/ GELLING AGENT/ THICKENER
Develops a cohesive structure with desired rheological properties
BINDER/ GELLING AGENT/ THICKENER
hydrophilic colloids that disperse and swell in the water phase
BINDER/ GELLING AGENT/ THICKENER
● synthetic cellulose derivatives (CMC, MC,HEC)
● alginates, such as sodium alginate;
● gums, such as xanthan gum;tragacanth
● carrageenan or calcium carrageenate
● carbomer;
● polyacrylates, clays (both natural processed bentonite and
synthetic clays).
● Precipitated silica
BINDER/ GELLING AGENT/ THICKENER
Titanium dioxide, mica
Coloring agent
-Toothpaste without _____________ are formulated with
preservatives (approx. 0.2% w/w) to prevent bacterial growth for
long term storage
ionic surfactants
sodium benzoate, dichlorophene, ethyl and methyl
paraben; formaldehyde
PRESERVATIVE
Low abrasive level / High humectant level
Type I Toothpaste
High abrasive level / Low humectant level
Type II Toothpaste
-Ribbon of substantial thickness
Toothpaste _______ (does not penetrate/penetrates) -substantially into
the bristle of the brush upon standing
does not penetrate
Toothpaste ________ (does not form/ forms) a string when finger is
pulled away from ribbon
does not form
T/F: -Rheological properties affect aesthetic and functional attributes
True
-Ideal rheological profile:
● Rigid gelatinous structure
● Becomes deformed and flowable with application of
minimal stress
● Reestablishes its original structure almost instantaneously
QUALITY PARAMETERS
1.Spreadability
2.Extrudability
3.Foaming property
4.Flavor
5. Preservative Efficacy
6.Viscosity
7.Color
8.pH
EFFICACY (PERFORMANCE) PARAMETERS
1.Antimicrobial activity
2.Whitening activity
-If the product claims to have a whitening effect
3.Hypersensitivity reduction
-If the product claims to be for sensitive teeth
