LA 5: Autoimmunity Flashcards
Are auto b and t cleks common
Yes. We just have ways to control them which is lost in autoimmjne diseases
Give some organ specific aids
Graves diesease, ms, type 1 d
Give some systemic aids
Ra, sle
Are aids ab or t cell mediated
Blth and usuallt th17 or th1 if t cell mediated
What causes the innate and adaptice in aids
Pamps on harmless self proteins
Explain graves disease (type II response)
Its auto ab mediated. An auto ab which binds the tsh recltor of thuroid and mimics the efect of tsh causinf excessive thyroid hormone release. This is because thyroid levels cant influence auto ab levels only tsh levels
Which other ttpe II reaponse is there where auto ab against ach recpeotsa on muscle causing internalisation so no muscle contraction
Myasthenia gravis
How would you study ab and determine if they cause phenotypes
Taken from blood snd purified, either use weatern blot to aee bindinf to self or inject into kouse and see change in phenotypes
Other than changing molecular mechanisms wg in graves, what other parhogenic effect do auto ab have
Desteuction or self cells
Haemolytic disease is an example ot cell desteucrion, give another
Thrombocytopenic purpura - auto ab against platelets
What type of sumptoms does immune thrombocytopenic purpura have
Bleeding from blood bessels causing brusing and rashes
What is another parhogenic effect of auto ab
Ic formation in type III wg in sle
Why arw ic depsoits systemic in type IiI
Necause ab are against nuclear ag which wre expressed on most cells/ in most cells wg dna. Forming immune complexes all over
What happens if ic deposited in blood bessels
Leakint and rashes appear
Auto ab eg in graves can cross placenta and cause same aid in baby. What is given to remove these
Blood transfusion
