L12- Mucosa 2 Flashcards
Which cells are ysed by nalt and the only one nalt uses for sg sampling
M cells
What are scfa a product of
Anaerobic digestion
Which srticle doscusess microbiota metabolites and host immunity
Blacher et al 2017
Which citamin by microbiota is involved in coagulation cascadr (blacher et al 2017)
K
Whoch modified bile acids do microbiota producr
Deoxycholic and lithocholic scid
Whoch anti inflam teceptor do deoxycjokic and lithocholic acid sctivate
Farnesoid x
How is farnesoid x anyi inflam
Increases epithelial integrity, also downregulstes nfkb pro inflam cytokines like tnfa, cox 1 and 2
How does butyrate provide energy for colonocytes
Atp generation and b oxidation (blacher 2017)
Whoch genes does butyrate regulate which allows mucin tpdouctikn
Genes for globlet differentiation and muc2
How do they allow tolerande to commensals
Induction of t regs, anti inflam eg the farnesoud x , muc production= lack of epithelial touching
What does b frsgillis cause epi crlls to secrete which forms more t regs
Tgf B
Which things which commensals release block dc maturation and therefore weak co stimulators = t reg induction
Tslp, tgf b
And il10 if they induce dc to release it
How can pathogens penetrating cell cause more t cell diff
Acticate dc better so stront co stimulatory wffect on t cells = activation
Tlr5 binding eg by dlagellin would usually cause nfkb cytokine release eg il6 and il23. What blocks nfkb translocation to nucleus
Some commensal microbes = anti inflam
How can mscrophages efficiently kill microbiota without mormal inflammation
They engulf and dont release cytokines and chemokines whicu cause inflammation = inhib macrophages
