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SP16 Anatomy Exam 3 > L43 Basal Ganglia > Flashcards

L43 Basal Ganglia Flashcards

1
Q

Parkinsons is due to
What
Where

A

degeneration of dopaminergic fibers in substantia nigra

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2
Q

Lenticular nucleus is composed of

A

Putamen

Globus pallidus

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3
Q

Basal ganglia composed of

A

Striatum
Globus Pallidus
Subthalamic nucleus
Substantia nigra

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4
Q

Striatum compsed of

A

Caudate nucleus
Nucleus accumbens
Putamen

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5
Q

Caudate
Shape
Location

A

C shape w/ head, body, tail

Part of wall of lateral ventricle

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6
Q

Huntingtons disease caused by degerenation of

A

degeneration of Caudate moreso than putamen

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7
Q

Huntingtons disease symptoms

A

Chorea
rigidity
cognitive disturbances

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8
Q

Chorea

A

Continuous rapid movement of face and limbs (distal)

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9
Q

Parts of substantia nigra

A

Compact

Reticular

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10
Q

Compact Substantia nigra
Pigmentation
Provide

A

pigmented nurons

provide dopaminergic projections to striatum

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11
Q

Reticular substantia nigra
Pigmentation
Location

A

Non-pigmented

Closer to cerebral peduncle

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12
Q

Motor loop

A 
learned movements
Direct pathway: 5 neurons
Indiret pathway: 7 neurons
Prefrontal cortex
Putamen
Globus pallidus
VA/VL
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13
Q

Cognitive loop

A 
motor intentions
Prefrontal cortex
Caudate
Globus pallidus
VA
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14
Q

Limbic Loop

A 
emotional aspect of movement (smile, gesture, etc.)
Inferior prefrontal cortex
Ventral Striatum (nuc. accumbens)
Ventral Pallidum
Dorsal Motor Nucleus
Inferior prefrontal cortex
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15
Q

Oculomotor loop

A 
voluntary saccades
Posterior Parietal cortex
Caudate
Substantia nigra 
VA
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16
Q

Loop progression

A 
Cortex
Striatum
Globus pallidus
Thalamus
Cortex
17
Q

Basal ganglia and movement

A

Cannot initiate movement but active during all movements

Modulates cortical activity in motor areas

18
Q

Limbic loop is rich in

A

dopaminergic neurons

19
Q

Oculomotor loop is activated when …… and disinhibits the ….

A

Activated when saccade is about to start, disinhibiting the superior colliculus

20
Q

Hemiballismus

A

Flailing rotatory movement often one side of body

21
Q

Putamen and globus pallidus

Organization

A

somatotopically

22
Q

Striatial projections from neurons in indirect pathway express these receptors

A

D2

23
Q

Striatial projections from neurons in direct pathway express these receptors

A

D1

24
Q

Parkinsons cardinal features

A

Bradykinesia
Resting tremor
Rigidity
Onset at 60

25
Q

Parkinsons histology

A

Substantia nigra compact part nuerons contain lewy bodies

26
Q

Parkinsons disease

A

Deep brain stimulation

Stem cell therapy

27
Q

Globus pallidus has extensive Basal Ganglia output to

A

thalamus

SP16 Anatomy Exam 3 (16 decks)

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