L40 Endocrine Pharm Flashcards
Hormone released in response to hunger
Ghrelin
Role of FSH in women
Ovarian follicle development
Conversion of androgens to estrogens
Role of LH in women
Ovarian steroidogenesis
Androgen production
Estrogen and progesterone production in luteal stage
Role of FSH in men
spermatogenesis
Role of LH in men
Testosterone production
Effects of vasopressin
Vasoconstriction
Reabsorption
V1 receptors are located on
Effect
Vascular smooth muscle
Vasoconstriction via G-alpha-q
V2 receptors are located on
Effect
Kidney tubules
water retention via G-alpha-s
Clinical uses of vasopressin
diabetes insipidous (passing large volumes of water)
Bleeding problems
bed wetting
Vasopressin antagonists used to treat
hyponatremia (low Na concentration in blood)
Thyroid hormone
Mainly in growing children
Stimulate GH secretion
Treatment of hyperthyroidism (3)
Thioamids: block synthesis
Anion inhibitors: block I transport
Iodine: High conc. inhibits synthesis
Thioamid mechanism
prevent hormone synthesis by inhibiting thyroid peroxidase catalyzed reactions
Block coupling of iodotyrosines
Low Ca
Parathyroid hormone released
Increase resorption
PTHR1 type of receptor
Galpha-s, Galpha-q
PTHR1 effects on osteoblasts
Induced RANKL leading to activation of osteoclasts
PTH effects on kidney
Increase Ca resorption
Decrease PO4-3 resoprtion
Vitamin D production
Calcitrol
Active form of vitamin D
From kidneys
Calcitonin
Increase bone formation
Decrease kidney resorption
Decrease Ca absorption by gut
Bisphosphonates
Prevent loss of bone mass
Major estrogens
E1: Estrone
E2: Estradiol
E3: Estriol
Mechanism of antagonizing estradiol receptors
Class 1 nuclear
Antagonists bind to AF-2, preventing the binding of co-activators needed for gene expression
Progesterone alone
Thickening of cervical mucus
