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AU16 Pharm3 > L40 Endocrine Pharm > Flashcards

L40 Endocrine Pharm Flashcards

1
Q

Hormone released in response to hunger

A

Ghrelin

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2
Q

Role of FSH in women

A

Ovarian follicle development

Conversion of androgens to estrogens

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3
Q

Role of LH in women

A

Ovarian steroidogenesis
Androgen production
Estrogen and progesterone production in luteal stage

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4
Q

Role of FSH in men

A

spermatogenesis

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5
Q

Role of LH in men

A

Testosterone production

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6
Q

Effects of vasopressin

A

Vasoconstriction

Reabsorption

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7
Q

V1 receptors are located on

Effect

A

Vascular smooth muscle

Vasoconstriction via G-alpha-q

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8
Q

V2 receptors are located on

Effect

A

Kidney tubules

water retention via G-alpha-s

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9
Q

Clinical uses of vasopressin

A

diabetes insipidous (passing large volumes of water)
Bleeding problems
bed wetting

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10
Q

Vasopressin antagonists used to treat

A

hyponatremia (low Na concentration in blood)

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11
Q

Thyroid hormone

A

Mainly in growing children

Stimulate GH secretion

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12
Q

Treatment of hyperthyroidism (3)

A

Thioamids: block synthesis
Anion inhibitors: block I transport
Iodine: High conc. inhibits synthesis

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13
Q

Thioamid mechanism

A

prevent hormone synthesis by inhibiting thyroid peroxidase catalyzed reactions
Block coupling of iodotyrosines

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14
Q

Low Ca

A

Parathyroid hormone released

Increase resorption

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15
Q

PTHR1 type of receptor

A

Galpha-s, Galpha-q

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16
Q

PTHR1 effects on osteoblasts

A

Induced RANKL leading to activation of osteoclasts

17
Q

PTH effects on kidney

A

Increase Ca resorption
Decrease PO4-3 resoprtion
Vitamin D production

18
Q

Calcitrol

A

Active form of vitamin D

From kidneys

19
Q

Calcitonin

A

Increase bone formation
Decrease kidney resorption
Decrease Ca absorption by gut

20
Q

Bisphosphonates

A

Prevent loss of bone mass

21
Q

Major estrogens

A

E1: Estrone
E2: Estradiol
E3: Estriol

22
Q

Mechanism of antagonizing estradiol receptors

A

Class 1 nuclear

Antagonists bind to AF-2, preventing the binding of co-activators needed for gene expression

23
Q

Progesterone alone

A

Thickening of cervical mucus

AU16 Pharm3 (10 decks)

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