L38 Hemostasis

Question 1

Formation of a clot

Answer 1

Vessel constriction
Platelet adhesion, activation, aggregation
Crosslinking of fibrin thru coagulation

Question 2

Upon injury, vascular endothelial cells produce

Answer 2

prostaglandin F2-alpha

Thromboxane A2

Question 3

During platelet adhesion, platelets bind to

Answer 3

Collagen
Fibronectin
Von Willebrand factor

Question 4

Activated platelets secrete..

Answer 4

Thomboxane A2 (constriction)
Prostaglandin F 2-alpha (constriction)
ADP (platelet aggregation)
Serotonin (constriction, aggregation)

Question 5

Platelet plug formation

Answer 5

Platelet integrin receptor binds to fibrinogen

Question 6

Cross linking of fibrin thru coagulation cascade

Answer 6

Fibrinogen cleaved by Thrombin
Forms Fibrin
Factor XIII crosslinks Fibrin to from blood clot

Question 7

When is tissue factor expressed in the blood

Answer 7

Only when tissue damage occurs

Question 8

How does thrombin become active

Answer 8

Carboxylation via oxidation of Vitamin K

Question 9

Extrinsic pathway

Answer 9

TF binds Factor VII
VII activates IX and X
IX is more important

Question 10

Enzyme that cross links fibrin

Answer 10

Factor XIII

Question 11

How does antithrombin work?

Answer 11

Binds to Factors in coagulation cascade

Question 12

How does protein C work

Answer 12

Zymogen that is activated by thrombin

Inactivates factors v, vii

Question 13

Tissue factor pathway inhibitor

Answer 13

reversibly inhibits factors v, vii

Question 14

Fibrinolysis

Answer 14

prevents blood clots from going and being problematic

Question 15

Indirect thrombin inhibitors

Answer 15

bind to antithrombin

Question 16

Thrombin, vitamin K mechanism

Answer 16

Prothrombin needs to oxidize reduced vitamin K

Drugs inhibit Oxidized vitamin K from becoming Reduced

Question 17

Aspirin mechanism

Answer 17

Inhibits thromboxane A2 synthesis