L35 Lipid lowering drugs Flashcards
Metabolic syndrome
cluster of biochemical and physio abnormalities associated with type II diabetes and cardio disease
fatty acids and insulin
High levels of free fatty acids associated w/ insulin resistance
Drugs to treat dyslipidemia
Fibric acid derivatives Nocitinic acid Bile Acid sequestrants HMG CoA Reductase inhibitors Cholesterol Absorption inhibitors
Fibric Acid derivatives
Effect
Reduce levels of triglycerides by increasing lipolysis, decreasing triglyceride production
Fibric Acid derivative mechanism
Agonist of PPAR alpha which acts on RXR receptor to stimulate beta oxidation in liver
Where is PPAR-alpha expressed?
liver Kidney heart muscle adipose
PPAR stands for
peroxisome proliferator-activated receptors
Vitamin B3
Niacin and niacinamide
B3 treatment for dyslipidemia
Has nothing to do with B3, which is why you must use niacin and not niacinamide
Nicotinic acid mechanisms and results
Agonist for GPR 109A: inhibits lipolysis and plaque formation
Inhibitor of DAG acyltransferase (blocks triglyceride production)
Increase HDL, Decrease triglycerides
GPR 109A function
G protein in macrophaes and adipose tissue
Inhibits lipolysis and atherogenic activity
Bile acid sequestrant mechanism
Liver converts cholesterol into bile
If bile levels are low from preventing bile acid resorption, liver converts more to bile
HMG CoA Reductase inhibitors AKA
Statins
Inhibit cholesterol biosynthetic pathway
Who are statins recommended for
People at risk of having a heart attack
Cholesterol absorption inhibitors mechanism
inhibit LDL formation
