L39 Hematopoiesis Flashcards
1
Q
Essential nutrients for hematopoiesis
A
Fe2
B12
Folic acid
2
Q
Most anemias are due to deficiency in
A
Iron
B12
Folic acid
3
Q
Heme biosynthesis mainly in
A
liver and bone marrow
4
Q
How is iron stored
A
As ferritin in macrophages, liver, spleen, bone, parynchymal liver cells
5
Q
Vitamins necessary for DNA synthesis
A
Folic acid
B12
6
Q
B12 deficiency
A
anemia and neurologic disease
7
Q
B12 deficiency is usually caused by
A
absorption deficiency NOT lack of consumption
8
Q
B12 absorption
A
combines with intrinsic factor
Forms complex
absorbed in ileum by pinocytosis
9
Q
Healthy vs sickle RBC
A
100 days vs 10
10
Q
Granulocyte colony stimulating factor
Granulocyte macrophage CSF
A
Used to treat chemotherapy induced neutropenia
11
Q
IL used to recover platlets
A
IL-11
