L36 Antidiabetic drugs

Question 1

A1C test

Answer 1

Insensitive to recent meals

Measures glycation of hemoglobin

Question 2

Standard of Care for treating diabetes

Answer 2

Sulfonylureas

Question 3

Regulation of Insulin release

Answer 3

ATP/ADP low (fasting), K channel open, cell hyperpolarized, L-type Ca closed, insulin not secreted
ATP/ADP high, K channel open, cell depolarized, Ltype Ca open, insulin secreted

Question 4

Sulfonylurea mechanism

Answer 4

Bind to subunit of Beta cell ATP K channel

Standard of Care

Question 5

Meglitinide use

Answer 5

Used before meals, short duration

Stops K channel

Question 6

Secretagogues

Answer 6

Sulfonylurea
Meglitinide
Incretins (work on GLP1 receptor)

Question 7

Incretins

Answer 7

Glucagon like peptide 1 acts on GLP 1 receptor to stimulate insulin release

Question 8

Metformin mechanism

Answer 8

Opposes glucagon

Inhibits respiratory chain complex I

Question 9

Thiazolidinediones mechanism

Answer 9

Effects on PPAR-gamma decrease insulin resistance

Question 10

Alpha-glucosidase inhibitors mechanism

Answer 10

inhibit digestion of glucose