L4 Chronic Inflammation and Healing

Question 1

Characteristics of cytokines

Answer 1

proteins, paracrine and autocrine, regulate chronic inflammation, can be pro-inflammatory, repair inducing, natural anti-inflammatory

Question 2

Examples of pro-inflammatory cytokines

Answer 2

IL-1

TNF

Question 3

What do pro-inflammatory cytokines cause

Answer 3

vasodilation -> adhesion -> chemotaxis -> activation of cells -> tissue breakdown, pain, platelet aggregation, fibroblast proliferation, angiogenesis

Question 4

What is a pannus

Answer 4

site of active bone loss in rheumatoid arthritis

Question 5

What is the process of wound healing

Answer 5

fibrin clot -> granulation tissue -> clot retracts and epidermal cells grow -> granulation tissue reabsorbed and wound healed

Question 6

What are the two types of cut healing and what are the characteristics

Answer 6

1. primary indention - edges of wound are joined with little inflammation
2. secondary indention - edges of wound not opposed, likely to involve granulation tissue, inflammation and scarring

Question 7

What are some factors influencing healing

Answer 7

nutrition, poor blood flow, diabetes, immunosuppression, infection