L3: Nephritic Syndrome Flashcards
Def of Nephritic syndrome
Etiology of Nephritic syndrome
Etiology of Nephritic syndrome
- Primary
…
Etiology of Nephritic syndrome
- secondary
Epidemeology of IgA Nephropathy
A very common cause of primary glomerulonephritis in adults.
Etiology of IgA Nephropathy
Mostly primary (idiopathic).
Pathology of IgA Nephropathy
Presentation of IgA Nephropathy
Most common presentations are:
① Episodes of gross hematuria often accompanying an upper respiratory infection.
② Asymptomatic hematuria with/without proteinuria.
TTT of IgA Nephropathy
Presentation of Nephritic Syndrome
- Hematuria & Proteinuria
- Decreased GFR & Oliguria
- Edema & Hypertension
- Manifestations of The Cause
Presentation of Nephritic Syndrome
- Hematuria & proteinuria
Presentation of Nephritic Syndrome
- GFR & Oliguria
Pathogenesis:
▪ Inflammatory infiltration and proliferation of resident glomerular cells.
Presentation of Nephritic Syndrome
- Edema & HTN
Presentation of Nephritic Syndrome
- Manifestations of The Cause
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INVx in Nephritic Syndrome
- Urine
- Blood
- Cause
INVx in Nephritic Syndrome
- Urine Studies
INVx in Nephritic Syndrome
- Blood Tests
INVx in Nephritic Syndrome
- INVx for the Cause
TTT of Nephritic Syndrome
- Symptomatic
- Cause
TTT of Nephritic Syndrome
- Symptomatic
- For hypertension: ACEI/ARBs - diuretics.
- For edema: Salt restriction - diuretics.
- For proteinuria: ACEI/ARBs.
TTT of Nephritic Syndrome
- TTT of Cause
….
Def of RPGN
- Clinical syndrome manifested by features of glomerular disease in the urinalysis and by
progressive loss of kidney function over a comparatively short period of time (days, weeks,
or a few months).
Pathology of RPGN
Etiology of RPGN
Etiology classified according to immunofluorescence pattern:
Etiology classified according to immunofluorescence pattern:
- Granular
▪ Systemic lupus erythematosus
▪ IgA nephropathy
▪ Endocarditis
Etiology classified according to immunofluorescence pattern:
- Linear
▪ Good-pasture syndrome
Etiology classified according to immunofluorescence pattern:
- Pauci Immune
▪ Granulomatosis with polyangiitis
▪ Microscopic polyangiitis
Pathogenesis of Good-Pasture Syndrome
- Autoantibodies directed against glomerular basement membrane antigens in the kidneys and alveolar basement membrane in the lungs .
Pathology of Good-Pasture Syndrome
- Linear deposition of Ig (usually IgG) along the GBM is pathognomonic.
- Crescent formation with variable degrees of necrosis.
Presentation of Good-Pasture Syndrome
- Rapidly progressive GN.
- Alveolar hemorrhage → hemoptysis.
TTT of Good-Pasture Syndrome
① Plasmapheresis.
② Immunosuppressive therapy.
GN & CKD
