L28: Parasitology Flashcards

1
Q

What are protozoa

A

single celled eukaryotes

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2
Q

cell structure similar/different to?

A
  • similar humans and plants (DNA nucleus bound)
  • different to bacteria and protozoa
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3
Q

what is special about protozoa transmission

A

involves more than one species

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4
Q

what causes malaria

A

plasmodium falciparum

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5
Q

what causes toxoplasmosis

A

toxoplasma gondii

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6
Q

what causes giardiasis

A

giardia lamblia

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7
Q

How is giardiasis commonly manifested

A

food poisoning, indigestion

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8
Q

giardia lamblia infects what?

A

enterocytes of the small intestine

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9
Q

how is giardia acquired

A

contaminated water

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10
Q

symptoms of giardia lamblia

A

watery diarrhoea

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11
Q

what does giardia do?

A

disrupts projections on enterocytes (vili?), disruption of nutrient absorption

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12
Q

trophozoites

A

parasites in eating phase

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13
Q

what happens when giardia is in an unfavourable environment

A

develops cyst wall around itself - protection, survival

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14
Q

life cylce of giardia

A

cyst swallowed - SI - to LI - cyst formation - shat out

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15
Q

diagnosis and treatment of giardia

A
  • cysts in faeces
  • metronizadole
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16
Q

toxoplasma gondii infects

A

gut of various cat species

17
Q

what is the mechanism of survival of t. gondii

A

oocyte/cyst formation - like giardia

18
Q

how can humans get infected with toxoplamsa gondii

A
  • eating oocytes in cat faeces
  • eating uncooked meat
19
Q

cycle of infection of toxoplasma gondii

A

infected cat - poop with organism - other organism infected by ingestion of organism - source of infection for next generation (can be rats, sheep - uncooked meat etc)

20
Q

where does toxoplasma gondii like to reside/multiply

A

brain

21
Q

toxoplasmosis how much percent is infected?

A

30%

22
Q

when in life is toxoplasma gondii usually caught

A

childhood

23
Q

symptoms of toxoplasmosis

A
  • mild, swollen lymph nodes, fever - non specific
24
Q

HIV relation to toxomplasmosis

A

untreated HIV can lead to toxoplasma gondii causing brain abcesses

25
Q

how does toxoplasma gondii affect vision

A

affect retina, scar tissue, blind spot

26
Q

Toxoplasmosis diagnosis

A
  1. serolology
    - IgM = acute infection (new AB, current)
    - IgG = chronic infection
  2. PCR for DNA in CSF
  3. Radiology
  4. Opthalmoscopy appearances
27
Q

Toxoplasmosis treatment

A

usually none for acute
- pregnant or AIDS –> sulphadiazine + pyramethamine

28
Q

What cuases potentially fatal malaria

A

plasmodium falciparum

29
Q

what causes benign malaria

A

plasmodium vivax

30
Q

what are the common malaria

A

plasmodium vivax
plasmodium falciparum

31
Q

plasmodium falciparium

A

malaria - potnetially fatal

32
Q

how is malaria transmitted

A

mosquitoes

33
Q

what mosquito transmits malaria

A

anopheles

34
Q

life cycle of malaria

A

mosquito - sucks blood from human - mosquito secretes saliva (anticoagulant) - parasite in glands - infected human - travel through blood - enter liver cells - ultimate target is RBC - exit liver to rbc

35
Q

malaria causes what symptoms

A

rigors, fever, shivering, sweating, headache

36
Q

malaria diagnosis

A

blood microscopy analysis

37
Q

P. falciparum differs from P. vivax in terms of RBC

A
  • P. falciparum can infect any circulating RBC - high % infected RBC - severe disease
  • P. vivax only infect immature/young RBC - small % infected RBC - mild disease
38
Q

P. falciparum infected RBC - consequence on capillary

A

surface of RBC gets chancges, expression of molecules, stick to capillary cells - clump up and block cappillaries - affect brain and kidney perfusion
- sequesteration?