L26: Hepatitis B Flashcards
1
Q
Hep B and C arise from?
A
the bloodstream
2
Q
Hep A source of infection
A
faeces
3
Q
How is Hep B transmitted
A
- mother to child
- child to child
- persistent infection following acquisition in infancy ot childhood
4
Q
Lab diagnostics for Hep
A
- microscopy
- culture (agar or borth)
- chemical test
5
Q
What is searched for in Hep B diagnosis
A
Hepatitis B surface antigen (HBsAg)
6
Q
Explain the structure of Hep B
A
- outer envelope: HBsAg
- central shell: core angtigen: HBcAg
- DNA inside central shell
7
Q
What is detected in the blood of Hep B infections
A
HBsAg clumps - forms spheres and tubuöes
8
Q
What determines HVC infectivity
A
HBeAg
9
Q
HBV concentrations in blood
A
high concentration of HBeAg - more infectious than low concentration of HBeAg
10
Q
How do infected cells get removed
A
cytotoxic killing
11
Q
How do infected cells get removed
A
cytotoxic killing
12
Q
HBV infection in adults vs infants
A
- infants, immune system not fully developed - infection consequences later in life - continued liver damage over decades
- adult, infection, symptomatic, cleared, immune bc make HBsAb
