L2: Endometriosis & Adenomyosis Flashcards

1
Q

Def of Endometriosis

A
  • Presence of endometrial tissue (glands & stroma outside normal uterine cavity.
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2
Q

Incidence of Endometriosis

A
  • Accurate assessment of incidence is difficult because laparoscopy & laparotomy are needed for diagnosis (it is found in 5-30% of all laparoscopies)
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3
Q

Etiology of Endometriosis

A
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4
Q

Etiology of Endometriosis

  • Implantation (transplantation) theory
A
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5
Q

Etiology of Endometriosis

  • Celomic metaplasia theory
A
  • Endometriosis develops from metaplasia of cells lining pelvic peritoneum.
  • No clinical or experimental support to this theory.
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6
Q

Etiology of Endometriosis

  • Vascular lymphatic theory
A
  • Endometrium is transported via vascular & lymphatic systems.
  • Evidence: Occurrence of endometriosis at distant sites (as umbilicus or Lungs
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7
Q

Etiology of Endometriosis

  • Genetic factor
A
  • Risk is 7 times greater if ist degree relative has endometriosis.
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8
Q

Etiology of Endometriosis

  • Immunologic Factors
A
  • Immune system may be altered in women รจ endometriosis because of decreased cell mediated cytotoxicity allowing endometrial cells to survive outside endometrial cavity.
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9
Q

PPT Factors for Endometriosis

A
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10
Q

Sites of Endometriosis

A
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11
Q

Sites of Endometriosis

  • Most Common
A
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12
Q

NE of Endometriosis

A
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13
Q

ME of Endometriosis

A
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14
Q

CP of Endometriosis

A
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15
Q

CP of Endometriosis

  • Symptoms
A
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16
Q

Symptoms of Endometriosis

  • Asymptomatic
A

โ€ฆ.

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17
Q

Symptoms of Endometriosis

  • Pelvic Pain
A
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18
Q

Symptoms of Endometriosis

  • Infertility
A
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19
Q

Symptoms of Endometriosis

  • Dys-Group
A
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20
Q

Symptoms of Endometriosis

  • Menstrual Disturbances
A

As menorrhagia or polymenorrhagia.

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21
Q

Signs of Endometriosis

A

refer to the gross appearance above.

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22
Q

INvx for Endometriosis

A
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23
Q

INvx for Endometriosis

  • Laparoscope
A
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24
Q

INvx for Endometriosis

  • Lab
A

Serum CA 125 โ€œincreased in endometriosis.

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25
Q

INvx for Endometriosis

  • Rad
26
Q

INvx for Endometriosis

  • Histopathology (Bx)
27
Q

Prophylaxis for Endometriosis

28
Q

Active TTT of Endometriosis

29
Q

Active TTT of Endometriosis

  • Expectant Medical TTT
30
Q

Expectant Medical TTT Endometriosis

  • NSAIDs
A

as pain killers and being anti-PGs.

31
Q

Expectant Medical TTT Endometriosis

  • Ovarian Suppression
32
Q

Ovarian Suppresion as TTT of Endometriosis

  • Pseudo-Pregnancy
33
Q

Ovarian Suppresion as TTT of Endometriosis

  • Pseudo-Menopause
34
Q

Danazol in TTT of Endometriosis

  • Structure
  • Eff
  • MOA
  • SE
35
Q

GnRH Agonists in TTT of Endometriosis

  • Examples
  • MOA
  • SE
36
Q

GnRH Antagonists in TTT of Endometriosis

  • Examples
  • Route of Adminstration
  • Advantages
37
Q

Surgical TTT of Endometriosis

38
Q

Surgical TTT of Endometriosis

  • Conservative
39
Q

Conservative Surgical TTT of Endometriosis

  • Indications
A
  • young age needing further pregnancy.
40
Q

Conservative Surgical TTT of Endometriosis

  • Methods
41
Q

Radical Surgical TTT of Endometriosis

42
Q

Radical Surgical TTT of Endometriosis

  • Indications
43
Q

Radical Surgical TTT of Endometriosis

  • Methods
44
Q

Def of Adenomyosis

A
  • It is the presence of endometrial glands and stroma in the myometrium, with adjacent smooth muscle hyperplasia.
45
Q

Incidence of Adenomyosis

  • Total
  • Age
  • Parity
  • Race
46
Q

Etiology of Adenomyosis

47
Q

NE of Adenomyosis

48
Q

ME of Adenomyosis

49
Q

CP of Adenomyosis

50
Q

CP of Adenomyosis

  • Symptoms
51
Q

CP of Adenomyosis

  • Signs
52
Q

INVx for Adenomyosis

53
Q

INVx for Adenomyosis

  • US
54
Q

INVx for Adenomyosis

  • MRI
55
Q

INVx for Adenomyosis

  • Hysteroscopy
A

Sub endometrial cysts.

56
Q

INVx for Adenomyosis

  • Laparoscsopy
A

โ€ฆ..

57
Q

INVx for Adenomyosis

  • Histopathology
A

Mostly from hysterectomy specimen

58
Q

TTT of Adenomyosis

  • Prophylactic
A

avoidance of predisposing factors

59
Q

TTT of Adenomyosis

  • Active
60
Q

Active TTT of Adenomyosis

61
Q

Active TTT of Adenomyosis

  • Medical
62
Q

Active TTT of Adenomyosis

  • Surgical