L19- syphilis and gonorrhea Flashcards

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1
Q

neisseria gonorrhea morphology

A

gram neg diplococci

has fastidious growth requirements

gram stains are not sensitive to all infections

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2
Q

syphilis dx

A

lesion- darkfield microscopy or direct immunofluoursence

seroligically- nontreponemal tests (screening) and treponemal (confirmation)

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3
Q

congenital syphilis

A

maculopapular lesions

nasal obstruction w/ infectious discharge

osteitis of nasal bones

neurosyphilis

hutchinsons triad

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4
Q

primary syphilis

A

entry through skin

local multiplication and dissemination to nearby lymph nodes

formation of syphilis chancre (principle lesion- will heal in 3-8 weeks w/ fibrosis)

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5
Q

neisseria gonorrhea causes what diseases

A

arthritis

conjunctivitis

more obvious:

pharyngitis, bacteremia, urethritis, cervicitis, salpingitis, PID, proctitis

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6
Q

latent syphilis progresses to

A

1/3 cases have spontaneous cure

1/3 develop into teritary

1/3 seropositive w/o disease

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7
Q

syphilis chancre looks like

A

scanty serous exudate w/ thin, grayish crust

base is smooth

border is raised, firm, red

indurated

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8
Q

the great imposter

A

syphilis

(treponema)

b/c it causes infections all over the body

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9
Q

gonorrhea virulence factors

(5)

A

antigenic variation of pili

nonpiliated phase variants

proteins (like porin) help it to attach

IgA protease

plasmid and chromosome mediated resistance to many abx incl fluoros

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10
Q

hutchinsons triad

A

notched incisors

interstitial keratitis

8th nerve deafness

seen in congenital syphilis

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11
Q

secondary syphilis

A

maculopapular rash

condyloma lata (mucosal warty lesions)

highly infective

immune complexes in artery walls

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12
Q

where does gonorrhea attack and colonize

A

enters through mucosal surface

women- endocervix and urethral colonization

men- anterior urethra colonization

mucopurulent discharge

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13
Q

syplilis morph

A

gram neg spirochete

slow motility

obligate internal parasite

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14
Q

tertiary syphilis

A

5-20 years after infection

neurosyphilis

cardiovascular syphilis (aortic aneurysm)

granulomata (gummas- look like warts)

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15
Q

treponema (syphilis) virulence factors

A

outer membrane proteins- help it stick to host cells

hyaluronidase- lets it infiltrate the blood stream

fibronectin coat- makes it appear familiar to the body so body doesn’t attack it

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16
Q

gonorrhea gold standard

A

nucleic acid amplification

(PCR)

17
Q

the body’s response to syphillis causes

A

lesions