L17 Flashcards
what is separated in a native page
size
charge
conformation
what is the secreting antibody? (used for like lung infections and such)
igA
what makes unique antibodies
random deletions in light and heavy chain
does everyone have unique antibodies
yes
heavy chain is composed of what subunits
V
D
J
whats the subunits in the light chain
only V and J
how many pieces are kept from each subunit of heavy and light chain
one from each subunit
what is clonal deletion
when the B-cell makes an antibody that binds the host (self destructive)
can a B-cell make a negative antibody
yes
what cells are activated upon antigen exposure
Naive B cells
whats the 2 routes of naive B cells
plasma cells or memory B cells
whats the factory of antibody production
plasma cell
do plasma cells last long
no
do memory B cells last long
yes
whats agglutination
clumping bacteria together through antibodies
neutralization
antibody blocking receptors on viruses so they can’t bind anything
opsonization
creating a coating around bacteria to enhance phagocytosis
activation of complement
antibody recruiting destructive bacteria to “punch” holes and lyse pathogens
antibody dependent cell mediated cytotoxicity
antibodies attached to target cell cause destruction by eosinophils and NK cells
in situ
experimental process
what are antigens most often
proteins
how are secondary antibodies created
by inserting the Fc tail from primary antibodies into a new organism
whats a primary antibody
created from binding to the antigen
polyclonal
natural immune reaction
monoclonal antibodies
single B cells made immortal
how to make monoclonal antibodies
fuse B cells with cancerous B cells to make them immortal
what causes membranes to fuse when making monoclonal antibodies
polyethylene glycol
what is the result os monoclonal production
1 single type of antibody
whats a trimer on a virus
antigen existing on the surface of the virus
