Krebs cycle Flashcards

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1
Q

What does the citrate synthase do?

A

1.The citrate synthase enzyme fuses Acetyle coa and oxaloaceacetate together
2.If there is too much ATP , citrate, succonylcoa & NADH it will inhibit the enzyme to making it
3.ADP stimulates the enzyme making it go through the kreb cycle to produce more ATP.

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2
Q

What happens in the aconitase?

A
  1. The citrate to isocitrate and the still the same 6 in citrate and 6 in isocitrate but this a isomerisation reaction what is reverisable.
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3
Q

What happen in the Isocitrate dehydrogenase?

A
  1. NAD + into NADH
    2.Isocitrate goes to alpha kentogultarate D.H and it loses one carbon to CO2 through decarboxlycation
    3.There are binding site, ATP binding and inhibits it and Ca+ ions and ADP stimulate to make ATP.
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4
Q

Alpha ketogulatarte D.H

A

1.Alpha kentogulatarate goes to Alpha kentogulatarate enzyme and it loses one carbon through decarboxylation to Co2 (Now 4 carbons)
2.NAD+ into NADH
3.Succinyl coa and NADH inhibits the enzymes to making stop production of it.
4. Calcium stimulates the enzyme to speed up ATP production

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5
Q

Succinyl coa synthesase

A
  1. CoA is added then removed
    2.GDP- GTP-ADP (gains phosphate)-ATP
    3.ATP blocks the GTP so the GTP-GDP
    4.Succinyl coa itno sucinate
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6
Q

Succinate dh enzyme

A

1.FAD- FADH2
2.Reverisble reaction
3.Can lead to pheochromocytotoma which os a tumour in the adernal medulla

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7
Q

Fumarase

A
  1. H20 is added to when it goes from fumarase to malate
  2. Deficinicy in this enzyme leads to a tumour leiomas- benign in smooth muscles
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8
Q

Malate dehydrogenase?

A
  1. NAD- NADH
  2. Reversible reaction
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