Kreb's Cycle (+Transition)

Question 1

Transition stage

Answer 1

Piruvic Acid (C3H4O3)

-CO2
+ CoA-SH
NAD+ -> NADH + H+

oxidative decarboxylation
pyruvate dehydrogenase

Acetyl CoA (C2H3O-S-CoA)

Question 2

Step 1

Answer 2

Acetyl CoA (C2H3O-S-CoA)
+
Oxaloacetic acid (C4H4O5)
+ H2O
- CoA-SH (cleavage)

citric synthetase

Citric Acid (C6H7O7)

Question 3

Step 2

Answer 3

Citric Acid (C6H7O7)

isomerisation
aconitase

Isocitric acid (C6)

Question 4

Step 3

Answer 4

Isocitric acid (C6)

-CO2
NAD+ -> NADH + H+

oxidative decarboxylation
isocitrate dehydrogenase

Alpha-keto-glutaric acid (C5)

Question 5

Step 4

Answer 5

Alpha-keto-glutaric acid

-CO2
+ CoA-SH
NAD+ -> NADH + H+

Succinyl CoA (C4)

Question 6

Step 5

Answer 6

Succinyl CoA (C4)

GDP <–> GTP
ADP -> ATP

substrate level phosphorylation (SLP)

succinylCoA kinase (C4)

Question 7

Step 6

Answer 7

succinylCoA kinase (C4)

FAD -> FADH2

oxidation
succinic dehydrogenase

Fumaric Acid (C4)

Question 8

Step 7

Answer 8

Fumaric Acid (C4)

+H2O
hydration
fumarase

Malic Acid (C4)

Question 9

Step 8

Answer 9

Malic Acid (C4)

NAD+ -> NADH + H+
oxidation
malate dehydrogenase

Oxaloacetic acid (C4)