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Metabolism CC > Kidney Embryology > Flashcards

Kidney Embryology Flashcards

1
Q

Mesonephric ducts

A

Wolffian ducts

Male origin

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2
Q

Paramesonephric ducts

A

Mullerian ducts

Female origin

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3
Q

In female

A

Mesonephric duct degenerates apart from lower portion which forms ureteric bud
Paramesonephric (Mullerian) duct forms oviduct

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4
Q

In male

A

Mesonephric duct forms male reproductive tract
Ureteric bud
Paramesonephric (Mullerian) duct degenerates

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5
Q

Metanephric kidney

A

Forms from mesonephric duct
Ureteric bud derived from mesonephric duct
Metanephric bud derived from mesenchyme

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6
Q

Adult structures from ureteric bud

A 
COLLECTING SYSTEM
Ureter 
Renal pelvis 
Major and minor calyces 
Collecting tubules
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7
Q

Adult structures derived from Metanephric bud

A 
EXCRETORY SYSTEM- NEPHRON
Renal glomerulus + capillaries Bowman’s capsule 
Proximal convoluted tubule 
Loop of Henle 
Distal convoluted tubule
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8
Q

Ascent of kidney

A

S1 to T12

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9
Q

Failure of kidney to ascend

A

Ectopic kidney

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10
Q

Kidney Agenesis

A

Failure of kidney to form

Associated with defect in ureteric bud formation

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11
Q

Bifid Ureter

A

Ureter splits in two
Duplicate kidneys
OR
Duplicate ureter

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12
Q

Pelvic kidney

A

Type of ectopic kidney
Usually 1
Often the 2 fuse- pancake kidney

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13
Q

Horseshoe kidney

A

Kidneys fuse in pelvic region
Form U shaped kidney
Can’t ascend due to inferior mesenteric artery

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14
Q

Polycystic kidney

A 
Kidney develop fluid filled cysts 
50% kidney failure by age 60 
Autosomal dominant 1:8001:1000 
Autosomal recessive 1:20,000 
Originally associated with defects in formation of tubules
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15
Q

Polycystic kidney disease

A

Cysts form in intact collecting tubules
Associated with increased cell division in tubule epithelium
Fill with fluid collected from glomerulus
Eventually break away from tubule

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16
Q

Polycystic Kidney Genetics

A

80-90% polycystin (PKD-1) mutation

10-15% PKD-2 mutation

17
Q

Polycystins

A

Localised to primary cilia (ciliopathy)

Involved in cell adhesion, Ca2+ transport + cell cycle

Metabolism CC (29 decks)

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