Ketone Metabolism

Question 1

2 major ketone bodies

Answer 1

B hydroxubutyrate (most abundant)
Acetoacetate
Acetone

Question 2

Ketones are produced in

Answer 2

liver during fasting

Question 3

Important energy source during fasting and prolonged exercise

Answer 3

Ketone

Question 4

Ketone is catabolyzed by peripheral tissues

Answer 4

Brain

Skeletal muscle

Question 5

Ketones are produced during

Answer 5

Intense exercise

Ketogenic diet

Question 6

B hydroxybutarate and acetoacetate are transported from liver to blood through

Answer 6

SLC16A6

Question 7

Ketones are able to traverse the brain and peripheral tissues through

Answer 7

Monocarboxylate Transporters
MCT1
MCT2

Question 8

Transports pyruvate and lactate across membranes

Answer 8

MCT1

MCT2

Question 9

When b hydroxybutyrate enters the brain, it is converted into

by the enzyme

Uses up

Reversible

Answer 9

Acetoacetate by the enzyme b hydroxybutyrate dehydrogenase

NADH

Question 10

B hydroxybutyrate is regulated by

Answer 10

SIRT3

Question 11

Acetoacetate can undergo spontaneous degradation into

Answer 11

Acetone and exhaled

Question 12

Majority of acetoacetate in peripheral tissues is converted into

by the enzyme

Answer 12

Acetoacetyl CoA by the enzyme Succinyl Coa 3

Ketoacid coenzyme A transferase (OXCT1/SCOT)

Question 13

Rate limiting step of ketone synthesis

Answer 13

Succinyl Coa 3 Ketoacid Coenzyme A Transferase

OXCT1 / SCOT

Question 14

Ketone is only metabolized in brain and muscle but not in the liver because it does not have

Answer 14

OXCT 1

SCOT

Question 15

Acetoacetyl Coa can act as substrate to produce

by enzyme

Answer 15

Acetyl coa by enzyme Thiolase

to TCA

Question 16

Oxidation of b hydroxybutyrate yields

Answer 16

26 moles of ATP including NADH

Question 17

Oxidation of acetoacetate yields

Answer 17

23 moles of ATP