Katzung Randoms

Question 1

The selective β1 agonist that has been most widely used in patients with heart failure is _________________. This parenteral drug produces an increase in cardiac output together with a decrease in ventricular filling pressure

Answer 1

Dobutamine

Question 2

Drug of choice for treating Neuroleptic Malignant Syndrome precipitated by D2-blocking antipsychotics

Answer 2

Diphenhydramine

Question 3

Drug of choice for filariasis

Answer 3

Diethylcarbamazine citrate

Question 4

What is used during therapeutic sedation for treating Serotonin Syndrome?

Answer 4

Benzodiazepine

Question 5

Dipeptidyl peptidase-4 inhibitor that is primarily excreted via the bile; hence, no dosage adjustment is needed in renal failure

Answer 5

Linagliptin

Question 6

DOC for P. vivax and P. ovale infections can relapse due to hypnozoites, which are dormant forms that remain in the liver.

Answer 6

Primaquine

Question 7

Syndrome that is idiosyncratic rather than predictable and appears to be associated with hypersensitivity to the parkinsonism-inducing effects of D2-blocking antipsychotics in certain individuals.

Answer 7

Neuroleptic Malignant Syndrome

Question 8

This syndrome is associated with a genetic defect in the RyR1 calcium channel of skeletal muscle sarcoplasmic reticulum that permits uncontrolled calcium release from the sarcoplasmic reticulum when precipitating drugs are given

Answer 8

Malignant Hyperthermia

Question 9

This syndrome occurs when overdose with a single drug, or concurrent use of several drugs, results in excess serotonergic activity in the central nervous system. It is predictable and not idiosyncratic, but milder forms may easily be misdiagnosed.

Answer 9

Serotonin syndrome

Question 10

Cardiotoxic effects of quinidine

Answer 10

QT prolongation and torsades de pointes arrhythmia