Kach: GI secretions Flashcards

1
Q

Histamine-2 receptors

A

When stimulated release hydrochloric acid

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2
Q

Swallowing is controlled by …

A

The medulla

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3
Q

Vomiting is controlled by…

A

The CTZ in the medulla

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4
Q

These medications block the release of Hydrochloric acid in response to Gastin

A

H² Antagonist

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5
Q

Cimetidine
Famotidine
Nizatidine
Ranitinde

Are examples of this medication

With this effect

A

Histamine ² Antagonist

Block the release of Hydrochloric acid in response to gastrin

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6
Q

____ work to suppress the secretion of Hydrochloric Acid into the Lumen of the stomach

A

PPI

( - azole)

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7
Q

Sucralfate

A

GI protectant coat the stomach and prevent further injury from acid

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8
Q

____ inhibit the secretion of gastrin and increase secretion of mucous liming

A

Prostaglandin

misoprostol

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9
Q

Cimetidine
Famotidine
Nizatidine
Ranitinde

Are examples of…
With what effect

A

Histamine ² Antagonist

Block release of Hydrochloric acid in response to gastrin

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10
Q

Famotidine (Pepcid AC)
Nizatidine (Axid AR)
Cimetidine (Tagamet HB)
Ranitinde (Zantac)

Are examples of

A

H² ANTAGONIST

Block release of Hydrochloric acid in response to gastrin

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11
Q

High levels of H² Antagonist can cause

A

Cardiac arrhythmias

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12
Q

Adverse effects

Diarrhea/ Constipation

Dizzy, headache, confusion, somnolencia, confusion, Hallucinations

Cardiac arrhythmias & Hypotension

Gynecomastia & Impotence

A

H² Antagonist

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13
Q

Drug interactions

Anticoagulant
Beta blockers
Alcohol
Quinididine, lidocaine, theophylline, chloroquine,
Benzodiazepine
Tri cyclic antidepressants

Nifedipine, pentoxifylline, Procainamide, carbamazepine

A

H² Antagonist

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14
Q

Used for:

Short term treatment Duodenal or benign gastric ulcers

Treat pathological hypersecretory conditions

Prophylaxis stress induced ulcers

Erosive GERD

Relief symptoms heartburn & acid indigestion

A

H² Antagonist

(-tidine)

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15
Q

This GI medicine can cause serious electrolyte imbalance in persons with rental impairment

A

Sodium Bicarbonate

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16
Q

Main drawbacks for this anti acid are Constipation & Acid rebound

A

Calcium Carbonate

17
Q

Magnesium Salt antacids have this side effect

A

Diarrhea

18
Q

Heart failure can occur with this antacid

A

Sodium Bicarbonate

Due to water retention

19
Q

Which type of GI medication can interfere with the absorption of other medication.

Due to changing the environment of the stomach

A

Antacids

Turn it Alkaline

20
Q

Treats

Upset stomach from hyperacidity

Prophylaxis for GI bleed / stress ulcer

Severe diarrhea

Metabolic acidosis

Certain drug intoxication

A

Antiacids

21
Q

Gastric rupture

Systemic Alkalosis
(Headache/nausea, irritation, weakness, tetany, confusion)

Hypokalemia

Gastric acid rebound

A

Antacids

22
Q

Omeprazole (Prilosec)
Esomeprazole (Nexium)
Iansoprazole (Prevacid)
Dexlansoprazole (Dexilant)
Pantoprazole (Protonix)
Rabeprazole (Aciphex)

How do they work

A

PPI

Supress secretion of Hydrochloric acid into the Lumen of the stomach

23
Q

Supress gastric secretion by inhibition of the hydrogn-potassium adenosine triphosphate on surface of gastric parietal cells

Blocking the final step in Acid production

A

PPI

(-Prazole)

24
Q

Treats

Duodenal ulcers
GERD
Errosive esophagitis
Benign active gastric ulcers

Long-term
Hypersecretory conditions
Maintenance of erosive esophagitis & ulcers

Used in combination with antibiotics for treatment of H pylori

A

PPI

(Prazole)

25
Q

Contradictions

Don’t use with rilpivirine (It can treat HIV infection)

A

PPI

(-Prazole)

26
Q

Side effects:

Diarrhea, cramps, N/V,

Insomnia, Vertigo

Tongue atrophy

Alopecia, Pruritus

Increase Bone Loss

Cancer

A

PPI
(-Prazole)

27
Q

Increased toxicity with use of

Benzodiazepine, phenytoin, warfarin

Decreased levels of

Ketoconazole ( Antifungal)
Theophylline (Bronchodilator)

Don’t use with antiretroviral drugs
Atazanavir
Nelfinavir
Saquinavir
Rilpivirine

A

PPI

(-Prazole)

28
Q

Sucralfate (carafate) is….

A

GI Protectant

Coat injured area and prevent further acid damage

29
Q

Adverse effects associated with Sucralfate (Carafate)

A

Mostly GI

30
Q

Sucralfate (GI protectant) Should not be given with this due to potentially Toxic combinations

A

Aluminum Salts

Used in

Antacids
Deodorant
Vaccines

31
Q

Treats

Short term and maintenance of active duodenal ulcers

Oral & esophageal ulcers due to radiation, chemotherapy, sclerotherapy

A

Sucralfate (Carafate)

GI protectant

32
Q

Forms an ulcer-adherent complex at the duodenal ulcers site, protecting it from bile,acid,salts, pepsin & Promotes Healing of Ulcer

Inhibits pepsin activity in gastric juices

A

Sucralfate (carafate)

GI protectant

33
Q

Inhibits gastric acid secretion and increases bicarbonate and mucous production

Protects the stomach

A

Prostaglandins

Misoprostol (Cytotec)

34
Q

Primary use to prevent NSAID-induced gastric ulcers

A

Prostaglandin

Misoprostol (cytotec)

35
Q

These GI drugs that inhibit gastric secretions and increase bicarbonate/ mucous production can INDUCE MISCARRIAGES

A

Prostaglandins

Misoprostol (cytotec)

36
Q

Saliva substitute should be avoid by these types of patients

A

HF, HTN, renal failure due to it makes the body absorb more Na

37
Q

Pancreatitic enzymes should be avoided by patients with these allergies

A

Pork

38
Q

misoprostol (class)

Do not give to..

A

Prostaglandins

Pregant women