Kach GI Drugs Flashcards
Cimetidine (Tagamet HB)
Famotidine (Pepcid AC)
Nizatidine (Axid AR)
Type of medication
Action
High levels can have this side effect
H² Antagonist
Block release of Hydrochloric acid
SE Heart arythmia
Gnawing burning pain a few hours after meals
This disease
Peptic ulcer
Leading cause of peptic ulcers
NSAIDS
This type of drug is used to treat duodenal ulcers
Benign gastric ulcers
GERD
Acid indigestion
Histamine ² Antagonist
Cimetidine (Tagamet HB) >12yrs
Famotidine (Pepcid)
Nizatidine (Axid) >12 yrs
Ranitinde (Zantac)
This type of medication is used for relief of GI hyperacidity
Variety of electrolyte issues
Antacids
Aluminum salts
Calcium salts
Magnesium salts
Sodium Bicarbonate
Treatment and maintenance of erosive esophagitis.
GERD
H pylori with antibiotics
PPI
Dexlansoprazole (Dexilant)
Esomeprazole (Nexium)
Iansoprazole (Prevacid)
Short term treatment of duodenal ulcers
Oral & esophageal ulcers due to radiation
Chemo/sclerotherapy
Gi protectants
Sucralfate (Carafate)
Prevention of NSAID induced ulcers in adults at high risk
Terminates Pregnancy
Prostaglandin
Misoprostol
Histamine ² Antagonist
Which one to use in a patient with liver disease
Nizatidine (Axid)
Adverse effects
Caution in pregnancy
Cardiac arrhythmias
Hypotension
Gynecomastia
Impotenc
Confusion/ Hallucinations
Histamine ² Antagonist
Cimetidine (Tagamet) can slow down absorption time of
Anticoagulant
Beta blockers
Lidocaine
Quindine
Theophylline
What type of med is it
Histamine ² Antagonist
Acid rebound happens in these types of meds
Calcium Antacids
Potential SE of these drugs is related to acid base balance & electrolytes
They also interfer with the absorption of medication due to changing the pH of the stomach
Antacids
Adverse affects
Gastric rupture
Systemic Alkalosis (headache, nausea, irritation, weakness, tetany)
Hypokalemia
Gastric acid rebound
DIARRHEA & CONSTIPATION
Antacids
Quickest acting PPI
Omeprazole Prilosec
SE
Loss strength
Vertigo
Insomnia
Apathy
Dream abnormalities
Dry mouth
Tongue weakness
Rash
Alopecia
Calcium absorption
Cancer
This med
PPI
Drug interactions
Increase
Benzodiazepine
Phenytoin
Warfin
Decrease
Ketoconazole
Ophylline
Antiviral / antiretroviral
PPI
Adverse effects of this medication are mostly GI
Constipation being the most common
Gastrointestinal protectant
Sucralfate (carafate)
Phenytoin, digoxin, Warfarin, fluoroquinolones antibiotics
&
Sucralfate
Have this precaution
Administer 2 hrs apart
Used to protect the stomach lining.
Inhibits gastric acid secretions & increases bicarbonate
Used to prevent NSAID gastric ulcers
Prostaglandin
Misoprostol
Emptying of the GI tract before surgery/ diagnosis
Short term treatment of Constipation
Chemical Stimulants
Bisacodyl (Dulcolax)
Castor Oil
Senna (Senokot)
Treatment of Constipation
Bulk forming Laxatives
Methylcellulose (Citrucel)
Polycarbophil (FiberCon)
Psyllium (Metamucil)
Short term treatment of Constipation
Osmotic Laxatives
Lactitol Pizensy
Lactulose Constilac
Magnesium (citrate, hydroxide, sulfate)
Polyethylene glycol Miralax
Docusate (Colace)
Glycerin (Sani-Supp)
Mineral oil
Belong to this group for treatment of Constipation
Lubricants
Speeds gastrointestinal recovery following surgeries
Treatment of opoid induced Constipation
Opiod Antagonist
Alvimopan (Entereg)
Methylnaltrexone bromide
Naloxegol (Movantik)
Naldemedine (Symproic)
Used to decreased diarrhea & help Constipation
Bulk forming Laxatives
Citrucel
Fibercon
Metamucil
Bulk forming Laxatives
Contradictions
Acute abdominal disorders
Appendicitis/ acute infections
Are Laxatives contradicted with acute surgical abdomen, fecal impaction, intestinal blockage
Yes
Patients with hemroids / recent rectal surgery require this laxative
Lubricant
Metoclopramide is a gastrointestinal stimulate.
Used for: GERD, Neausa / Vomiting, promote GI movement
Side effects:
Tardive dyskinesia, seizures, depression
Treatment of neausa and vomiting associated with surgery
Phenothiazines
Suffix - Azine
Promethazine = treatment Motion Sickness
Treatment of Neausa and vomiting associated with Chemotherapy
5 HT³ Receptor Blockers
Suffix -Tron
Granisetron
Ondansetron
Palonosetron
Adverse effects
Neuroleptic malignant syndrome
Tremors
Muscle spasms
Photo sensitive
Pink to brown urine
Phenothiazines
Suffix- Azine
Surgery antimetics
These antimetics have the SE of
Prolonged QT syndrome
Risk of torsade de Pointes
5 HT³ receptor blocker
Suffix - Tron
Ondansetron Zofran