Judah Folkman

Question 1

what was the drug studied by Judah Folkman

Answer 1

endostatin

Question 2

what is a criteria that is needed to be considered for the trial?

Answer 2

• tumors must be in a place that’s easy to biopsy

Question 3

what phase is endostatin in?

Answer 3

in phase 1

Question 4

that does phase 1 mean

Answer 4

the effectiveness of the drug is unkown

Question 5

what was the experiment that changed scientists mind about angiogenesis

Answer 5

when a tumor was implanted in the cornea of the eye. Blood vessels grew (not normal) & then blood vessels retracted when the tumor was removed

Question 6

what drug was studied that was originally used for ppl w/ morning sickness

Answer 6

thalidomide

Question 7

does thalidomide inhibit blood vessel growth?

Answer 7

no

Question 8

t/f
the metabolized version of thalidomide inhibits blood vessel growth

Answer 8

true

Question 9

what is the molecule that suppresses metastasis?

Answer 9

angiostatin

Question 10

angiostatin is aka an

Answer 10

angiogenesis inhibitor

Question 11

explain the stimulator/ inhibitor effect

Answer 11

removal of primary tumor causes its inhibitor to be removed causing the previously dormant metastasized tumors to grow