Cancer Treatment Part 1 Flashcards
what cancer has shown to have become resistant to most forms of traditional treatment?
lung
breast cancer incidence has increase and its likely due to
increased screening
genomics in breast cancer gave…. and proved…
-a threshold between good and bad signature
- patients w/ good signature did not benefit from additional chemotherapy
genomics in b-cell lymphomas showed that DLBCLs were a group of
several subtypes of B-cell neoplasias
with the use of gene expression DLBCLs were subcategorized into
DLBCL: diffuse large B-cell lymphoma
- PMBL- primary mediastinal B-cell lymphoma
- GCB DLCL- germinal center B-cell DLBCL
- ABC DLBCL- activated B-cell like DLBCL
the use of gene expression arrays allowed tumors to be categorized by
outcome
karyotype
biochemical alterations
the use of gene expression arrays allowed for better
- survival rate predictions
- treatment options
what is the most common bone cancer in golden retrievers and humans?
osteosarcoma
what is a functional constraint to the development of chemotherapeutics?
only a small set of defective proteins are suitable targets for drug cancer development
what is an example of inhibiting tumor growth by targeting downstream signals?
-blocking Ras w/ farnesyltransferase
- blocking RAF w/ RAF inhibitors
define a therapeutic window
a range of drug dosage where efficacy is the highest and toxicity is the lowest
give an examples of how successful cancer drugs can produce several responses in tumors
- cells die via apoptosis
- induced differentiation
treatment with what lead to complete remission in 85% of patients w/ promyelocytic leukemia
treatment w/ trans retinoic acid
relative of vitamin A
many chemotherapeutics damage chromosomes causing
mitotic catastrophe sending cell into apoptosis
selective targeting of cancer cells involves the use of
-staurosporine
-camptothecin
