Cancer Immunotherapy

Question 1

infusion of large #’s of T cell can

Answer 1

kill cancer cells and induce remission

Question 2

identifying what can improve the outcomes for many patients?

Answer 2

genes critical to cancer’s immune resistance

Question 3

CRISPR has found _____ genes that play a role in _________ susceptibility

Answer 3

• 100
• T cell

Question 4

AML and solid tumors cells highly express

Answer 4

CD47

Question 5

what identifies healthy cells vs. those to be phagocytosed

Answer 5

SIRPa

Question 6

explain how to turn dont eat me to eat me signal

Answer 6

by introducing anti-CD47 antibodies that block CD47/SIRPa

Question 7

bacteria are naturally drawn to

Answer 7

hypoxic & necrotic cells

Question 8

what bacteria has killed mouse tumors by activating the immune system?

Answer 8

salmonella

Question 9

killing cancer w/ bacteria is more complicated and less predictable in humans due to

Answer 9

recurrence, infection control

Question 10

define neutrophils

Answer 10

WBCs that respond to post-op inflammation

Question 11

characteristics of neutrophils

Answer 11

• cross the blood-brain barrier
• destroy residual glioblastoma cells

Question 12

are neutrophils successful in humans?

Answer 12

no

Question 13

what is an example of drug delivery via immune cells

Answer 13

drug-loaded liposomes inserted into neutrophils

Question 14

CAR stands for

Answer 14

chimeric antigen receptor

Question 15

explain CAR T-cell therapy

Answer 15

a patients WBCs are harvested and genetically engineered to target an antigen on their cancer cells

Question 16

CAR T-cell therapy was first approved to treat

Answer 16

recurring B cell acute lymphoblastic leukemia (ALL)

Question 17

new and improved CARs add ___________ and ___________ to improve targeting of T cell attack

Answer 17

• co-stimulatory signaling domains
• extra receptors

Question 18

what is the cost of CAR T cell therapy

Answer 18

475,000

Question 19

what CART-T cell therapy has been approved for patients 25 years and younger that have relapsed at least twice

Answer 19

kymriah

Question 20

MR1 was previously ONLY known to

Answer 20

present bacterial antigen to a different T cell line

Question 21

MR1T cells recognize and kill

Answer 21

MR1-positive cancer cells

inducing maturation of dendritic cells

Question 22

how does MR1T cells kill MR1-positive cells

Answer 22

by recognizing self-antigens presented by MR1 protein

Question 23

what virus contains a cancer cell antigen in it outer protein shell

Answer 23

papillomavirus pseudoviruses

Question 24

papillomavirus pseudoviruses given orally to mice caused

Answer 24

regression of colon adenocarcinomas w/
-3X survival time
-prevent relapse

Question 25

tetanus vaccine targets

Answer 25

cytomegalovirus (CMV)

Question 26

CMV is found in

Answer 26

brain tumors