JH IM Board Review - Heart Failure I Flashcards
What is the prevalence of HF in the United States?
6million
What is the incidence of HF in the United States?
Up to 550,000 each yr.
What is the root of HF?
The heart can no longer meet the metabolic demands of the body.
What is the definition of HF?
A complex clinical syndrome that occurs when the heart or circulation is unable to meet the metabolic demands of peripheral tissue at normal cardiac filling pressures.
==> It can occur in pts w/ nl or depressed systolic function.
What is the common division of HF?
- Systolic ==> HF w/ reduced EF = HFrEF.
2. Non systolic HF ==> HFpEF.
What is the MC type of HF?
Systolic (60%).
What is the type of HF that is increasing in prevalence?
Non systolic HF.
What are the 2 MC of HF?
- CAD — MI.
2. HTN.
What are the 8 major causes of acute decompensated HF?
- Decompensation of preexisting chronic HF from a precipitating factor.
- Hypertensive crisis (eg hypertensive emergency).
- MI.
- Acute tachyarrhythmia.
- Acute endocarditis ==> severe regurgitation.
- Acute DCM.
- Cardiac tamponade.
- High-output HF.
What are the 7 main precipitating factors that may lead to decompensation of preexisting chronic HF?
- Natural progression.
- Excessive fluid/salt intake.
- Meds nonadherence.
- Infection.
- New MI.
- Metabolic stress (eg anemia, hyperthyroidism).
- Medication use (NSAIDs ==> Na retention).
What are the 3 circumstances under which an AMI may lead to ADHF?
- Papillary muscle is involved ==> Mitral regurgitation.
- Massive anterior MI.
- RV infarct resulting in a low cardiac output state.
What are the 8 main causes of high output HF?
- Thyrotoxicosis.
- Beri beri.
- Paget.
- Sepsis.
- Severe anemia.
- AV fistula.
- Persistent tachycardia (eg atrial arrhythmias).
- Liver disease.
What are the 3 potential cell targets of a cardiomyopathy?
- Myocytes.
- Non myocytes.
- Myocardial interstitium.
What is the MC of DCM?
CAD.
What is the 2nd MCC of DCM?
Idiopathic.
What is the 3rd MCC of DCM?
Inherited/familial.
What is the usual presentation of DCM?
ADHF.
What percentage of DCM improves spontaneously?
25-30%.
What is the prognosis of a DCM with a NYHA IV?
1y mortality is 50%.
What are some important predictors of poor prognosis in DCM pts?
(4)
- Hyponatremia.
- High cardiac filling pressures.
- Low cardiac index.
- Poor kidney function.
What is the difference in the mechanism of systolic and nonsystolic HF?
Systolic ==> Impaired ejection.
Non systolic ==> Impaired filling.
What are the main physical findings in systolic HF?
- S3 and/or S4.
- Weak carotid upstroke.
- Displaced apical impulse.
What are the main physical findings in non systolic HF?
3
- S4 is more common.
- Normal carotid upstroke.
- Forceful apical impulse.
What is the type of cardiomyopathy that Duchenne leads to?
DCM
What are the 3 types of HCM?
- Hypertrophy of the LV.
- Hypertrophy of the RV.
- Hypertrophy of both.
What is the type of HF that HCM leads to?
HFpEF.
Rarely HFrEF
What is the ddx of HCM?
- Hypertrophy from HTN (Hypertensive HCM).
- Renal failure.
- Fabry.
What is the age of onset of HCM?
Hypertrophy is almost always present by age 30y and sx by age 40y.
What is the screening recommendation for all 1o relatives of HCM pts?
All first degree relatives should be undergo screening w/ echocardiography and electrocardiography (ECG).
What are the 2 functional types of HCM?
- Obstructive.
2. Nonobstructive.
What are the 2 conditions under which obstructive HCM is worse?
- Increased contractility.
2. Decreased preload.