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Mice > Jax Handbook - Chap 4 Characteristics of Popular Strains > Flashcards

Jax Handbook - Chap 4 Characteristics of Popular Strains Flashcards

1
Q

Which of the following gene is responsible for age-related hearing loss?

a. Hear1 del
b. Gnat2 pflx3
c. Cdh23 ahl
d. None of the above

A

c. Cdh23 ahl

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2
Q

Which of the following is INCORRECT about strain 129S1/SvImJ?

a. Widely used for targeted mutation due to availability of ES cell lines
b. The color is white-bellied agouti
c. May build up shaving under water bottle resulting in wet-drowned mouse
d. Are prone to hearing loss

A

d.Are prone to hearing loss

This substrain does not develop hearing loss, but some 129 substrains do

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3
Q

When does hearing loss occur in the susceptible 129 strains?

a. Immediately after birth
b. 3-5 months of age
c. After 1 year of age
d. After 1.5 yrs of age

A

b. 3-5 months of age

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4
Q

Which of the following is INORRECT about A/HeJ mice?

a. High Inter- and intra-strain aggression
b. Primary cleft palate sometimes found in newborn easily induced by cortisone
c. Sometimes are born with eyes open
d. They are albino

A

a. High Inter- and intra-strain aggression

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5
Q

Which of the following characteristics are common among A/J and A/WySnJ mice?

a. High percentage of mammary adenocarcinomas in multiparous females
b. Carry Cdh23 ahl mutation
c. High incidence of primary lung tumors
d. Albino
e. All of the above
f. a and c only
g. c and d only

A

e. All of the above

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6
Q

Which of the following is INCORRECT about AK/J mice

a. Hyper responsive to diets containing high level of fat and cholesterol
b. High spontaneous frequency of Lymphatic leukemia before 1 year
c. Viremic at birth and all express the ecotropic retrovirus AKV
d. They are albino

A

a. Hyper responsive to diets containing high level of fat and cholesterol

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7
Q

Which of the following is INCORRECT about B6.129P2-Apoe tmUnc/J?

a. Have increase in total plasma cholesterol level
b. Mostly used in Cancer research
c. Develop fatty streaks in proximal aorta at 3 months
d. Are congenic with targeted mutation

A

b. Mostly used in Cancer research (atherosclerosis research)

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8
Q

Which of the following is the only correct characteristic of B6D2F1 mice?

a. Mixed haplotype enables mice to accept tissue transplant from both parental strains
b. F1 congenic strains
c. Poor breeder and producers
d. They have brown color

A

a. Mixed haplotype enables mice to accept tissue transplant from both parental strains

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9
Q

Which of the following is the only correct characteristic of the BABL/cJ?

a. Extremely high inter and intra-strain aggression
b. Very resistance to radiation
c. Develop high spontaneous mammary tumors
d. Resistant to MMTV

A

a. Extremely high inter and intra-strain aggression

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10
Q

Which of the following mouse strains are used for autism model?

a. BABL/cJ
b. MA/MyJ
c. BTBR T+ tf/J
d. CAST/EiJ

A

c. BTBR T+ tf/J

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11
Q

Which of the following mice considered a good model for induced rheumatoid arthritis?

a. BALB/c J mice
b. BUB/BnJ
c. C3H/HeJ
d. DBA/1LacJ

A

b. BUB/BnJ

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12
Q

Which of the following genes cause retinal degeneration and blindness by weaning age?

a. Gnat2 pflx3
b. Cdh23 ahl
c. Pde6brd1
d. Blind cantc
e. c and d

A

c. Pde6brd1

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13
Q

Which of the following characteristics are TRUE for C3H/HeJ?

a. Blind after 3 weeks
b. High incidence of hematomas
c. Have agouti color
d. Females sexually mature very early (25 days)
e. All of the above
f. a, b and c

A

e. All of the above

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14
Q

T/F. C3HeB/FeJ develops calcareous heart deposits in almost all retired breeder.

A

True

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15
Q

Which is the only INCORRECT statement about C57BL/6J?

a. Homozygous for Cdh23 ahl and hearing loss after 10 months of age
b. Prone to hydrocephalus and malocclusion
c. Prone to glaucoma
d. Barbering is common
e. Prone to dermatitis
f. Highly susceptible to development of atherosclerotic lesions
g. Most widely used inbred strain
h. Resistant to radiation
i. Females may die bearing first litter or may cannibalize first litter

A

c. Prone to glaucoma

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16
Q

T/F. Strain C57BLKS/J has high frequency of congenital malformation of toes.

A

True

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17
Q

Which of the following is INCORRECT about C57L/J?

a. High incidence of Hodgkin’s-like reticulum cell neoplasm by 18 months
b. Highly susceptible to EAE (experimental allergic encephalomyelitis
c. Extremely high hematocrit
d. High frequency of mammary tumors

A

d. High frequency of mammary tumors

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18
Q

T/F: 129P1/ReJ are widely used in production of targeted mutations due to availability of embryonic cell lines (ES).

A

True

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19
Q

Which of the following is INCORRECT characteristic for CBA/J mice?

a. Is the only CBA substrain of mice that carries Pde6brd1 resulting blindness by weaning age
b. Used to study granulomatous experimental autoimmune thyroiditis (G-EAT)
c. Resistant to chronic whole body radiation
d. Their color is agouti

A

c. Resistant to chronic whole body radiation

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20
Q

Which of the followings is INCORRECT characteristic of DBA/1J mice?

a. Homozygous for Cdh23 ahl hearing loss after 10 months of age
b. Extremely susceptible to autogenic seizures after one year of age
c. Model for rheumatoid arthritis
d. Calcareous heart deposit are found in almost all retired species
e. Mice squeal when handled and very jumpy
f. Oldest inbred strain
g. Extreme susceptibility to alcohol, morphine and related opioids

A

g. Extreme susceptibility to alcohol, morphine and related opioids (that’s DBA/2 mice)

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21
Q

T/F. DBA/2J aging mice develop progressive eye abnormalities that mimic human hereditary glaucoma.

A

False

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22
Q

Which of the followings is INCORRECT characteristic of FVB/NJ mice?

a. Pronuclei of zygotes are large and easily identified
b. Are poor breeders
c. Homozygous for Pde6brd1
d. Have not been found to develop spontaneous tumors
e. Aggressive males

A

b. Are poor breeders

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23
Q

T/F. HRS/J mice are hairless start losing hair at about 10 days old

A

True

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24
Q

KK/HIJ mice serve as a model of noninsulin-dependent type 2 diabetes

A

True

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25
Q

LP/J mice develop bony lesions that resemble human otosclerosis

A

True

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26
Q

About 5% of MA/MyJ mice develop cysts in neural and intermediate lobes pituitary.

A

False

The incidence is 50%

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27
Q

Which of these two strains have large pronuclei?

a. SWR/J
b. FVB/NJ
c. 129P1/ReJ
d. C57BL/6J
e. a and b
f. c and d

A

e. a and b

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28
Q

Which of the followings is INCORRECT characteristic of NOD.CB17-Prkdcscid mice?

a. Have severe combined immunodeficiency
b. Prone to insulinitis and diabetes by 3 months of age
c. Have high incident of thymic lymphomas
d. Life span about 8.5 months
e. Excellent host for xenografts

A

b. Prone to insulinitis and diabetes by 3 months of age (free of insulinitis and DM; control for NOD.ShiLtJ mice)

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29
Q

NOD.Cg-PrkdcscidIl2rg tm**1wjl/SzJ mice :

a. Are congenic
b. Have spontaneous mutation
c. Have targeted mutation
d. All of the above

A

d. All of the above

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30
Q

Which of the followings is INCORRECT about NOD.Cg-PrkdcscidIl2rg tm1wjl/SzJ?

a. Life span is short~8.5 months
b. Superior model for HIV because of improved lymphoid expansion
c. Superior human hematopoietic engraftment
d. Significant loss of NK activity
e. Does not produce detectable serum immunoglobulin

A

a.Life span is short~8.5 months (short lifespan seen in NOD.CB17-Prkdcsckid/J mice)

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31
Q

Which of the followings is INCORRECT characteristic for NOD/ShiLtJ?

a. Polygenic model for type 1 diabetes
b. The incidence of diabetes is higher and develops faster in males compared to females
c. Susceptibility to diabetes influenced by environmental factors
d. Homozygous for Cdh23 ahl

A

b. The incidence of diabetes is higher and develops faster in males compared to females

32
Q

T/F. NoncNZO10/LtJ is a polygenic model of human type 1 diabetes

A

False

Polygenic model of human metabolic
syndrome and type 2 diabetes.

33
Q

PWK/PhJ mice are used to facilitate selection of immunoglobulin-competent hybridomas.

A

True

34
Q

Which of the followings is INCORRECT characteristic for SJL/J mice?

  • a.*Homozygous for Pde6brd1, blindness after 2 weeks of age
  • b.*Susceptible to EAE
    c. Predominant tumor type is pre-B cell lymphoma
    d. Very calm and non-aggressive behavior
    e. Both NOD and SJL/J are derived from Swiss mice
A

d.Very calm and non-aggressive behavior (SJL mice can be very aggressive)

35
Q

Which of the followings is INCORRECT characteristic for SWR/J mice

a. They are outbred mice
b. Aging mice exhibit high incidence of lung and mammary tumors
c. Highly susceptible to EAE
d. Female develop polydipsia at 6-19 months of age
e. Remanded for generation and propagation of transgenic mice due to high response to hormones and large pronuclei
f. 50% develop primary lung tumors

A

a. They are outbred mice

36
Q

Which of the following strains do not have a homozygous mutation for Cdh23 ahl (age related hearing loss)?

a. C3H/HeJ
b. 129S1/SvImJ
c. BALB/cJ
d. C57BL/6J
e. LP/J
f. MA/MyJ

A

a. C3H/HeJ

37
Q

Which strain does not have a homozygous mutation for *Pde6brd1 * gene (blindness)

a. BUB/BnJ
b. CeH/HEj
c. C57BL/6J
d. CBA/J
e. NON/SHiLtJ
f. PL/J
g. SJL/J
h. FVB/NJ

A

c. C57BL/6J

38
Q

Which of the following mice are animal models used for EAE?

a. C57L/J
b. PL/J
c. SJL/J
d. All of the above
e. b and c only

A

d. All of the above

39
Q

Which of the these mice are wild-derived inbred strains?

a. SPRET/EiJ
b. JF1/Ms
c. CAST/EiJ
d. All of the above
e. None of the above

A

d. All of the above

40
Q

Which of the following male mice are considered aggressive?

a. SJL/J
b. BALB/cJ
c. FVB/NJ
d. All of the above
e. a and b only

A

d. All of the above

41
Q

Which of these mice do not have agouti coat color

a. CeH/HeJ
b. CBA/J
c. DBA/1J
d. SM/J
e. WSB/EiJ
f. PWK/PhJ

A

c.DBA/1J

42
Q

Which of these mice are resistant to diet induced atherosclerosis?

a. C57BL/6J
b. DBA/2J
c. SM/J
d. All of the above

A

b. DBA/2J

43
Q

Which of the following mice are described as jumpy and difficult to handle according to Jax technicians?

a. DBA/1J
b. SPRET/EiJ
c. JF1/Ms
d. CAST/EiJ
e. All of the above

A

e. All of the above

44
Q

Which of the these mice have spontaneous absence of corpus callosum

a. I/LNtj
b. BTBR T+tf/J
c. CBA/J
d. JF1/Ms
e. a and b only
f. All of the above

A

e. a and b only

45
Q

Which of these strains are immunocompromised?

a. SJL/J
b. NOD.CB17-Prkdcscid
c. NOD.Cg-PrkdcscidIl2rg tm1wjl/SzJ
d. All of the above
e. b and c only

A

e. b and c only

46
Q

What is the average number of pups weaned per a C57BL/6 J female?

a. 10
b. 6
c. 3
d. 4

A

b. 6

47
Q

Which is the correct order of the highest pups weaned by strains?

a. C57BL/6J, FVB/NJ, SJL/J, LP/J
b. FVB/NJ,SJL/J, C57BL/6J, LP/J
c. LP/J, C57BL/6J. FVB/NJ, SJL/J
d. SJL/J, C57BL/6J, LP/J, FVB/NJ

A

b. FVB/NJ,SJL/J, C57BL/6J, LP/J

48
Q

What mouse strain has the lowest wean: born percentage?

a. NZB/BINJ
b. C57BL/6J
c. BALC/cJ
d. SM/J

A

a. NZB/BINJ

49
Q

Which female has the lowest maternal age at birth of the first litter?

a. C57BL/6J
b. CAT/EiJ
c. AKR/J
d. SJL/J

A

c. AKR/J

50
Q

Which female has the longest optimal breeding age?

a. C57BL/6J
b. DBA/2J
c. AKR/J
d. SJL/J

A

a. C57BL/6J

51
Q

C57BL/6 are prone to what neoplasms? Which type of tumor is rare in this strain?

A

lymphoma, hemangiosarcoma, pituitary adenoma

mammary tumors rare

52
Q

Which strain exhibits aplasia of the corpus callosum?

A

BALB/c

53
Q

Which strain is resistant to amyloidosis?

A

BALB/c

54
Q

Which strain has a very high incidence of mammary tumors?

Which strain has a very low incidence of mammary tumors?

A

High - C3H/He

Low - C57BL/6, FVB/N

55
Q

Which strain is prone to testicular teratoma?

A

129/SV

56
Q

Which strain is the most frequent source of embryonic stem cells?

A

129

57
Q
A
58
Q

What kind of diabetes is NOD a model for, and at what age does it manifest

A

Insulin dependent (Type 1) diabetes mellitus by 30 weeks

59
Q

Which strain develops spontaneous alopecia areata

A

C3H/He

60
Q

Which strain is susceptible to experimental autoimmune encephalomyelitis?

A

SJL (Swiss Jim Lambert)

61
Q

Which strains are homozygous for Pde6brd1, and what condition does this lead to?

A

C3H, CBA, FVB/N, SJL, SWR

retinal degeneration

62
Q

Which immunodeficient mouse model lacks only natural killer activity? What is the gene and chromosome affected?

A

Beige

Lyst

chromosome 13

63
Q

The Beige mouse is a model for what disease of granulocytes?

A

Chediak-Higashi syndrome

64
Q

Which immunodeficient mouse model is primarily T-cell deficient? What is the gene and chromosome affected

A

Nude

Foxn1

chromosome 11

65
Q

Which immunodeficient mouse model is primarily T- and B-cell deficient, with some “leakiness”? What is the gene and chromosome affected?

What strain is a “nonleaky” alternative?

A

SCID

Prkdc

chromosome 16

Rag1

66
Q

Which immunodeficient mouse model is lacks B-cells and lympokine activated killer cells, but nas norm al T-call and NK cell function?? What is the gene and chromosome affected

A

XID

Btk

X-chromosome

67
Q

Which immunodeficient mouse model is deficient in B-cells, T-cells and NK cells?

A

NODscid

68
Q
A
69
Q

which strain has a high incidence of leukemia?

A

AKR

70
Q

Which strain has no endogenous retroviruses?

A

SWR/J

71
Q

Which strain has a high frequency of spontaneous respiratory tumors?

low frequency of spontanous repiratory tumors?

A

A (high)

B6 (low)

72
Q

Which strains have increased incidence of mammary tumors?

Decreased incidence?

A

Increased - C3H, A, DBA/2

Decreased - BALB/c, C57BL, AKR

73
Q

Which strains develop Diabetes Insipidus?

A

NDI

SWR

SWV

74
Q

Which strains are prone to deafness from cochlear degeneration?

A

129

A/J

DBA/2

C57BL/6

BALB/c

75
Q

Which strains are prone to auditory seizures?

A

AKR

BALB/c

CBA

C57

DBA/2

Mice (20 decks)

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