BB AALA Ch10 Rodents Flashcards
1
Q
- Which of the following symptoms IS NOT usually seen in a mouse with moderate pain?
a. Roughened haircoat
b. Piloerection
c. Teeth grinding
d. Eyes closed or squinted
e. Hunched posture
A
c
2
Q
- Which of the following IS NOT a sign of moderate pain in rats?
a. Increased or decreased water intake
b. Porphyrin staining around nose and eye
c. Eye closed or squinted
d. Brachypnea, increased 30% under baseline
e. Pica, chewing on cage
f. Twitching, tremor
g. More aggressive or docile
A
d. Tachypenia increased 30% over the base line
3
Q
- Which of the following is CORRECT regarding guinea pigs experiencing pain?
a. Exaggerated startle reflex
b. Stampeding more
c. Unusually quiet
d. Porphyrin section around eyes and nose
A
c
4
Q
- Which of the following considered general clinical signs of pain in mice?
a. Absence of nest building
b. Stretching
c. Back-arching
d. Increased low rearing
e. Reduced high rearing, reduced exploring
f. Cannibalism of offspring
g. Altered sleep-wake cycle
h. Altered group behavior (conspecific grooming, separation)
i. Lying with legs crossed
j. All of the above
A
j
5
Q
- True or False: Genetically modified rodents may have unexpected variability in their response to anesthetics compared with background strains.
A
True
6
Q
- Which of the following can affect the animal response to anesthetic?
a. Obesity
b. Pregnancy
c. Bedding type (e.g., raw pine shaving)
d. All of the above
A
d
7
Q
- The choice of rodent anesthetics depends on which of the following statements?
a. Duration of a procedure
b. Scientific compatibility
c. Whether a procedure is survival or non-survival
d. The invasiveness of the procedure
e. All of the above
A
e
8
Q
- Which of the following IS NOT required for rats prior to use of injectable anesthetics?
a. For transported animals a period of 24-72 hours of acclimation
b. Fasting for at least 24 hours
c. Measuring body weight
d. All of the above are required
A
b
9
Q
- True or False: Rodents are obligate nasal breathers.
A
True
10
Q
- Which of the following statements is COREECT regarding maximum volume per site using IM route in mice?
a. 0.1 ml
b. 0.05 ml
c. 0.025 ml
d. 0.01 ml
A
b
11
Q
- What is the proper gauge of needle to be used for lateral tail vein injection in mice?
a. <18G
A
c
12
Q
- What is the maximum volume per site and needle gauge for SC (scruff or back) in rats?
a. 5-10 ml, <20 G
A
a
13
Q
- What is the maximum intravenous infusion volume for mice, gerbils and hamsters?
a. 100 ml/kg
b. 10 ml/kg
c. 5 ml/kg
d. 25ml/kg
A
d
14
Q
- What is the maximum intravenous infusion volume for rats and guinea pigs?
A
20 ml/kg
15
Q
- Why it is extremely important to provide thermal support peri-op and continuing throughout until full recovery?
a. Because rodents have a high surface area to body mass
b. Because fur is clipped
c. Because liquid disinfectant is used
d. Because animal is in contact with conductive surfaces such as metals
e. All of the above
A
e
16
Q
- True or False: Charcoal filtration is an effective method for removing nitrous oxide gas.
A
False
17
Q
- True or False: Isoflurane can be administrated IV in mice when mixed with Intralipid.
A
True
18
Q
- Which of the following is INCORRECT regarding MAC
a. It stands for minimum alveolar concentration
b. Anesthetic with high MAC have a relatively high potency
c. (MAC) is defined as an end- tidal concentration of inhaled anesthetic required to prevent purposeful movement (positive motor response) in 50% of subjects to somatic noxious stimuli.
d. MAC is comparable to ED50 (effective dose when 50% of patients are anesthetized).
A
b
19
Q
- Which of the following is the CORRECT ranking of MAC of volatile anesthetic from low to high?
a. isoflurane, halothane, sevoflurane, desflurane
b. sevoflurane, desflurane, halothane, isoflurane
c. isoflurane, sevoflurane, desflurane, halothane
d. halothane, isoflurane, sevoflurane, desflurane
A
d
20
Q
- True or False: The primary negative side effect of all volatile anesthetic is an agent-dependent depression of cardiovascular system.
A
True
21
Q
- True or False: Isoflurane creates more profound myocardial depression compared to halothane
A
False, reverse is true
22
Q
- True or False: Isoflurane may be the best inhalant anesthetic agent to be used in rodent models of human traumatic brain injury.
A
True
23
Q
- Cardioprotective effects of isoflurane can last how many days following the anesthetic episode in mice?
a. 5 days
b. 1 day
c. 10 days
d. 14 days
A
d
24
Q
- Which of the following is INCORRECT about isoflurane?
a. Gastrointestinal system is generally spared of side effects
b. Isoflurane is only minimally metabolized by the liver
c. Isoflurane can have both protective and deleterious effect on lungs
d. Isoflurane should never be used for pregnant or neonatal rodents
A
d
25
Q
- True or False: Isoflurane may have a hyperalgesic effect if the inhaled concentration becomes too low. Therefore all the painful procedures should be completed before lowering the dose of isoflurane.
A
True
26
Q
- Which of the following is TRUE about halothane?
a. Halothane is a potent bronchodilator
b. Halothane has neuroprotective effects
c. Of all the volatile inhalants, halothane has been shown to have the most d. extensive effects on the cardiopulmonary system during anesthesia
e. all of the above
A
d
27
Q
- True or False: Repeated anesthesia with halothane and sevoflurne produces a peripheral leukopenia and lymphopenia that lasts several days
A
True
28
Q
- Which of the following is a major disadvantage of using Sevoflurane?
a. Slow induction
b. Production of a nephrotoxic by-product called Compound A
c. Slow recovery
d. Deleterious effect on pulmonary system
A
b
29
Q
- Which of the following anesthetic require highly specialized vaporizer due to its low boiling point
a. Halothane
b. Sevoflurane
c. Desflurane
d. Methoxy flurane
A
c
30
Q
- Which of the following is the most soluble volatile agent in the blood and brain, thus the most potent inhalant?
a. Methoxyflurane
b. Desflurane
c. Isoflurane
d. Enflurane
A
a
31
Q
- True or False: Enflurane has lower margin of safety in rats compared to Isoflurane; therefore, the use of this inhalant in rodents is not recommended.
A
True
32
Q
- Which of the following statements is INCORRECT regarding use of CO2 for anesthesia?
a. It can be used for short-term procedures
b. It is highly aversive to both mice and rats
c. It has a wide margin between anesthesia and euthanasia
d. It increases corticosterone release in rats
A
c
33
Q
- Which of the following is INCORRECT regarding nitrous oxide?
a. Low solubility in the blood
b. Minimal cardiopulmonary depression
c. It is seldom used in rodents
d. Low toxicity
e. Mostly used as a sole anesthetic agent for surgeries
A
e
34
Q
- Which of the following is correct about using xenon as anesthetic?
a. Has profound neuroprotective effects due to NMDA antagonism
b. Has cardioprotective effect
c. A only
d. Both a and b are correct
A
d
35
Q
- True or False: Sevoflurane and isoflurane potentiate seizure and arrhythmia activity in rats given concurrent high doses of IV bupivicaine.
A
True
36
Q
- Which of the following routes IS NOT recommended for the injectable anesthetics because the induction of anesthesia is prolonged and variable on onset?
a. IM
b. IP
c. SC
d. IV
A
c
37
Q
- Which of the following is INCORRECT about ketamine?
a. Ketamine is a noncompetitive NMDA receptor antagonist
b. It has an analgesic property
c. It produces adequate muscle relaxation
d. Salivation is increased, but laryngeal and pharyngeal reflexes are retained.
e. Occasional production of apneustic ventilation
f. Ability to produce a cataleptic state characterized by CNS excitement rather than depression
A
c
38
Q
- Which of the following is INCORRECT about Xylazine?
a. Produces sedation and relaxation
b. May elicit significant tachycardia and sinoarterial
c. Sensitizes the myocardium to catecholamines
d. It has analgesic property
e. Increases peripheral vascular resistance
A
b, causes bradycardia, it is atropine sensitive
39
Q
- Which of the following drugs IS NOT a xylazine antagonist?
a. Yohimbine
b. Tolazoline
c. Flumazenil
d. Atipamezole
e. idazoxan
A
c
40
Q
- Adverse side effect of ketamine/xylazine includes:
a. Hypothermia up to 4ºC over 60 minutes of anesthesia
b. Ocular lesions
c. Muscle necrosis following IM injections
d. All of the above
A
d
41
Q
- Which of the following is INCORRECT about Medetomidine?
It is an alpha-2 adrenoreceptor agonist
Medetomidine specificity for alpha-2 adrenoreceptor is lower than xylazine
Medetomidine has fewer side effects
Atipamezole can be used for reversal
A
b, Meditomidine has 10X more specificity for alpha-2 adrenoreceptor than xylazine
42
Q
- True or False: Male mice are more resistant to the effect of ketamine/meditomidine combination)
A
False, reverse is true
43
Q
- Which of the following drug can be used for diazepam (valium) reversal?
a. Atipamizole
b. Nalbuphine
c. Yohimbine
d. Flumazenil
A
d
44
Q
- Ketaset plus is combination of ketamine with which of the following drugs?
a. Butyrophenones
b. Xylazine
c. Diazepam
d. Promazine
A
d
45
Q
- Which of the following may be observed animals when combination of Ketamine/promazine used as anesthetic?
a. Suppression of protective reflexes (coughing, swallowing)
b. Produce only light anesthesia
c. Hypothermia and hypotension
d. All of the above
A
d
46
Q
- Neuroleptic agents such as azperone, droperidol, haloperidol belong to which group of drugs?
a. Butyophenones
b. Phenothiazine
c. Benzodiazipam
d. opioids
A
a
47
Q
- Which of the following statements is INCORRECT regarding sodium pentobarbital?
a. Minimal analgesic effect
b. Mice and rats may experience initial hyperexcitability
c. Assessment of pedal reflex is a poor indicator of anesthetic depth
d. Broad margin of safety
e. Male rats clear the drug more rapidly than females
A
d
48
Q
- Which of the following is a long acting barbiturate?
a. sodium pentobarbital
b. pentobarbitone
c. Thiobarbital (Inactin)
d. Thiopental
A
c