[Jan] BBV154, Bharat Biotech’s single-dose intranasal vaccine for Covid-19 Flashcards

1
Q

What is an intranasal vaccine?

A
  • Vaccines are most commonly administered as injectable shots into the muscles (intramuscular) or the tissue just between the skin and the muscles (subcutaneous).
  • However, with intranasal vaccines, the solution is squirted or sprayed into the nostrils and inhaled instead of injecting it.
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2
Q

Benefits?

A
  • Overcome barriers to delivery and administration that come with producing and distributing injectable vaccines
  • may be able to tap an additional set of immune cells found in the tissues lining the nose, mouth and lungs
  • cut down on the need for syringes, needles and other components like alcohol swabs, as they are not injected
  • Eliminates needle-associated injuries and infections
  • does not require trained healthcare workers
  • single-dose,
  • Studies have shown that targeting the immune response to the upper respiratory tract provides critical protection(hence better targeted)
  • SARS-CoV-2 virus shows a proclivity to dwell in the upper respiratory tract for a prolonged period of time, a safe and efficacious nasal vaccine is well-placed to target the literal entry point of the virus into the body.
  • current vaccines did not prevent infection in the nose and lungs,intranasal vaccines can prevent them -> hence it will Will help reduce transmission of the virus
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3
Q

potential setbacks?

A

These vaccines have mostly been made using live, weakened viruses, but have never cleared clinical trials.

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4
Q

CONCERNS

A
  • being used only for influenza till date

- cannot be used on certain groups of people,-> particularly those who have compromised immune systems.

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