[feb]Plumbing the ‘dark’ genome for new genes

Question 1

context?

Answer 1

Study by a team of the University of Cambridge to find the emergence of new genes in the genome of living organisms and the mechanisms involved.

Question 2

Human Genome Project?

Answer 2

-international scientific research project with the goal of determining the base pairs that make up human DNA

Question 3

About current study?

Answer 3

• catalogued 1,94,000 novel regions in the human genome -> referred as novel Open Reading Frames or as nORFs.
• mutations in nORFs have physiological consequences -> involved in cancer
• nORFs can form structures,undergo biochemical regulation ,targeted by drugs.
• identified nORFs in Plasmodium falciparum(malaria causing parasite)