[Jan] Angiogenesis

Question 1

Context?

Answer 1

Researchers are working to develop transgenic zebrafish model by the use of the CRISPR/Cas9 gene-editing tool to further study the compensatory angiogenesis mechanism in the tumour microenvironment.

Question 2

What is it?

Answer 2

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis.

It is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue.

However, it is also a fundamental step in the transition of tumours from a benign state to a malignant one. Deregulation of angiogenesis is the main reason for tumour growth and progression.