Iron Metabolism Flashcards
inorganic substances that are required by your body in order to develop and grow properly
minerals
where is iron mainly absorbed
stomach and duodenum
in what form is iron soluable and reaily absorbed
ferrous 2+
how much dietary iron is typically absorbed
10%
those with low stomach acid absorb_____ iron
less
what are the fates of absorbed Fe2+
- reoxidized and stored in ferritin
- bound to transferrin
what is the major regulator of iron absorption
hepcidin. induces internalization and digestion of ferroportin
what happens to old RBCs
recycled by phagocytes in the spleen
what is heme broken down into
bilirubin
why do pregnant women lose more Fe
fetal brain development. iron requirement is 9x greater
what is the execretory mode of iron loss
there is none
Iron deficiency results in what kind of anemia
microcytic
hypersegmented neutrophils are typically seen in what type of anemia
macrocytic
what is siderblastic anemia
enough iron but it isnt incorporated due to problems with red cell maturation
what is the test for siderblastic anemia
prussian blue
low iron and ferriton, high TIBC is an indication of
iron deficiency anemia
normal/high iron and ferritin is an indication for
thalassemia
blood test that measure the iron in the liquid part of the blood
serum iron
the remaining transferrin (not being used to transport iron)
UIBC (unsaturated iron binding capacity)
the serum iron plus UIBC
TIBC (total iron binding capacity)
the blood test that measure the amount of iron stored in the body
ferritin
a highIBC, TIBC, or transferrin typucally indicates
iron deficiency
how is transferrin saturation calculated
serium iron / total iron binding capacity x 100
what is the most common form of poisoning death in children < 6
hemochromatosis
