Inflammation

Question 1

IL-6, IL-1, and TNF-alpha are all

Answer 1

pyrogenic cytokines

Question 2

what are the 5 cardinal signs of inflammation

Answer 2

1. swelling
2. redness
3. tenderness
4. heat
5. loss of funciton

Question 3

what is dolar? calor?

Answer 3

tenderness, heat

Question 4

Th17 is caused by what pathogens? what innate immune system components?

Answer 4

bacteria and fungi

neutrophils

Question 5

Th1 is caused by what pathogens? what innate immune system components?

Answer 5

viruses, protozoa, mycobacterium

interferon, macrophages, NK cells

Question 6

Th2 is caused by what pathogens? what innate immune system components?

Answer 6

helminths, arthropods

mast cells, eosinophils

Question 7

thrombopoietin produces

Answer 7

platelets

Question 8

G-CSF produces

Answer 8

neutrophils

Question 9

M-CSF produces

Answer 9

macrophages

Question 10

GM-CSF produces

Answer 10

dendritic cells

Question 11

IL-5 is associated with

Answer 11

eosinophils

Question 12

TNF-alpha is associated with

Answer 12

dendritic cells

Question 13

Increased PMN produces a ______ shift

Answer 13

left

Question 14

a patient with CGD does not sufficently produce

Answer 14

superoxide radicals O2- (damage to genes that produce NADPH) chronic infections

Question 15

what are the steps of endothelial cell activation

Answer 15

1. Loss of vascular integrity
2. increased expression of adhesion molecules
3. change toward prothrombotic state
4. cytokine production
5. upregulation of HLA molecules

Question 16

what is the steps of a neutrophil entering site

Answer 16

rolling, activation, adhesion, migration

Question 17

what response is most effective against intracellular pathogens

Answer 17

Th1

Question 18

which type of inflammation are most likely to produce the cardinal sign

Answer 18

Th17