AA metabolism II

Question 1

Most folates in the diet are in what form

Answer 1

DHF

Question 2

folates are essential to neural tube development in the first _____ weeks

Answer 2

12

Question 3

high folate may mask peripheral indications of _____ deficiency

Answer 3

B12

Question 4

unmetabolized FA may interfere with

Answer 4

DHFR, MTHFR

Question 5

what inhibits thymidine sythase (dump ->dtmp)

Answer 5

fluorodeoxy-uracil

Question 6

what doews methotrexate do to the folate cycle

Answer 6

blocks TS and DHFR. blocks purine and thymidine synthesis. causes megablastic anemia

Question 7

MTHFR polymorphisms may link to

Answer 7

dementia

Question 8

deficiency of B12 leads to ________,if severe ______

Answer 8

MMA, pernicious anemia

Question 9

what is needed for B12 absorption

Answer 9

intrinsic factor

Question 10

a hypersegmented neutrophil is indicative of

Answer 10

pernicious anemia

Question 11

the transulfuration pathway is dependent upon what cofactor

Answer 11

B6

Question 12

high homocysteine is a risk factor for

Answer 12

atheroscelerosis and dementia

Question 13

cystinuria is when

Answer 13

poor reabsorption of acidic AA -> kidney stones

Question 14

cystinosis is

Answer 14

pediatric condition lysosomal accumulation of cystine. fanconi syndrome

Question 15

homocystinuria is

Answer 15

defects in CBS. displacement of lens down and in

Question 16

marfan syndrome lens is displaced

Answer 16

down and in

Question 17

If a patient has MSUD, what AA levels are expected to be high

Answer 17

leucine and isoleucine