Iron metabolism Flashcards
Low iron in men or post-menapausal women should always be followed up for possible_____________?
GI bleed
Why don’t vegetarians absorb iron as well as people who eat meat?
Non-heme (Fe3+) in veggies is taken up less avidly than Heme iron (Fe2+?) found in meat.
Treatment for Hemochromatosis?
Phlebotomy!!!!!!
Deficiency in HFE gene (autosomal recessive)
HFE gene codes for hepcidin so defect = decr. hepcid and iron overload
HFE Hemochromatosis
Ferritin of
Iron deficiency anemia!!!!!
Wherer is Fe primarily absorbed in the body?
Proximal small bowel (duodenum)
What is ferric iron?
Fe3+, found in veggies, insoluble at physiological pH
-oxidized to Fe2+(ferrous) in acid of stomach
Which is absorbed better, Fe2+ or Fe3+?
Fe2+ !!!!!
ferrous
ferrous
ferrous
How is Fe3+ transported in blod?
transferrin
How is Fe2+ stored in cells?
ferritin
Key regulator of systemic iron homeostasis?
Hepcidin
Increased hepcidin = _________ intracellular iron. Which can lead to what?
increased
Iron deficiency seen in Anemia of Chronic Disease
Decreased hepcidin results in ______ extracellular iron.
increased
**leads to iron overload
1 mL blood = _____ mg Fe?
0.5
Classic triad of Hereditary Hemochromatosis?
- DM
- hepatomegaly
- Hyperpigmentation
Deficiency in HFE gene (autosomal recessive)
HFE gene codes for hepcidin so defect = decr. hepcidin and iron overload
HFE Hemochromatosis
Where is Fe primarily absorbed in the body?
Proximal small bowel (duodenum)