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IHO week 1 > Diebel Innate Immunity > Flashcards

Diebel Innate Immunity Flashcards

1
Q

Cathelcidin: What is it? What shape is it? alpha or beta?

A

antimicrobial peptide

alpha- helical

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2
Q

Defensins; What is it? What shape is it?

A

antimicrobial peptide

Beta-strand peptides (

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3
Q

Where do HNP alpha-defensins 1-4 come from?

A

PMNs, monocytes, lymphocytes

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4
Q

Where do HD (alpha) (human defensins) 5 and 6 come from?

A

Paneth cells

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5
Q

Where do Beta defensins come from?

A

mucosal surface epithilia

also monocytes, macrophages, and dendritic cells

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6
Q

How do defensins work?

A

Break holes in microbial membranes

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7
Q

Name 6 examples of PAMPs:

A

LPS

peptidoglycan (PGN)

lipopeptides

flagellin

bacterial DNA

viral dsRNA

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8
Q

Stimulation of TLRs by PAMPs and DAMPs initiates signaling cascades leading to activation of which TFs?

A

AP-1

NF-kB “the mother of all transcription factors”

IRFs 3 and 7

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9
Q

TLR 1 + 2:

PAMP?

Produces?

A

Triacylated lipoproteins, PTG, LPS

Inflammatory cytokines (ICs)

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10
Q

TLR 2+6:

PAMP?

produces?

A

Diacylated lipoproteins

ICs

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11
Q

TLR 3:

PAMPs?

produces?

A

dsRNA, tRNA, siRNA

ICs, type 1 INF

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12
Q

TLR 4:

PAMPs?

produces?

A

LPS, paclitaxel

ICs, type 1 INF

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13
Q

TLR 5:

PAMPs?

produces?

A

Flagellin

ICs

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14
Q

TLR 7:

PAMPs?

produces?

A

ssRNA, Imidazoquinolines, guanisine analogs

ICs, type 1 INFs

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15
Q

TLR 8:

PAMPs:

produces:

A

ssRNA, Imidazoquinolines

ICs, type 1 INF

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16
Q

TLR 9:

PAMPs?

produces?

A

CpG DNA, CpG ODNs

ICs, type 1 INFs

17
Q

TLR 10:

PAMPs?

produces?

A

profilin like proteins

ICs

18
Q

4 hallmarks of inflamation:

A

edema

hyperthermia

local hypoxia

influx fo WBCs

19
Q

Histamine:

A

increased vascular permiability

20
Q

Prostaglandin E2:

A

vasodilation, increased vascular permiability

21
Q

Leukotriene D2:

A

neutrophil chemotaxis

increased vascular permiability

22
Q

Leukotriene D4:

A

increased vascular permiability

23
Q

TNF:

Macrophages

A

pyrogenic (fever causing)

stimulates expression of E-selctin

24
Q

IL-1:

Macrophages

A

endogenous pyrogen

stimulates expression of E-selectin

25
Q

IL-8:

Macrophages

A

chemotaxis

26
Q

IFN-gama:

A

NK cells

activation of phagocytic cells and NK cells

27
Q

Three principle changes in tissue during acute inflammation:

A

increased blood supply

increased capillary permiability

increased leukocyte migration to affected area

28
Q

Inflammation type with higher proportion of neutrophilis and activated helper T cells?

A

acute

29
Q

Inflammation type with hight proportion of macrophages, cytotoxic t cells and B cells?

A

chronic

30
Q

What does TNF-alpha do?

A

I don’t know, look it up!!!

31
Q

E-selectin:

A

adhesion molecule of endothelial cells that grabs onto passing WBCs

IHO week 1 (13 decks)

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