Hematopoietic virus cases

Question 1

Patient with saddleback fever pattern caused by a segmented dsRNA, non-enveloped, icosahedral virus infecting the pro-erythroblasts has been infected by which pathogen?

Answer 1

Colorado tick fever virus

Question 2

A patient’s blood smear show’s owl’s eye cells infected with dsDNA, enveloped, virus of the Herpes family. What virus do they have and how would you treat?

Answer 2

Cytomegalovirus (HHV-5)

supportive therapy unless immunocompromised then give Ganciclovir

**virus latent in CD34+ (monocyte–>macrphage)

Question 3

Patient presents with a rash following a fever. They have a virus of the Herpes family with affinity for CD4+ cells. What virus do they have and how would you treat?

Answer 3

HHV6-7—roseola (exanthem subitum)

tx: supportive—ganciclovir and cidofovir in immunocompromised

Question 4

Patient presents with spleenomegaly, sore throat, and fever caused by a dsDNA, enveloped virus with affinity for epithelial cells of the oropharynx that also has a latent stage in B-cells. What virus is this?

Answer 4

EBV-HHV4

infectious mono

Question 5

A patient undergoing chemotherapy for breast cancer presents with a dsDNA virus infecting the epithial cells and B-cells. You treat with ganciclovir, cidofovir, and fascarnet. What was the virus>/

Answer 5

Kaposi sarcoma herpes virus (HHV-8)

Question 6

Slapped cheek, ssDAN, NON-enveloped, infecting erythroid progenitor cells. What is the virus?

Answer 6

parvovirus B19

**supportive care

Question 7

Virus causing acute T cell lymphmo via upregulatioin of viral TF Tax which drives proliferation and blocks apoptosis. This is a ssRNA(+) virus. What is it and what is the tx?

Answer 7

Human T lymphotrophi virus

Chemo and or bone marrow transplant

Question 8

Genetic material of HIV?

Answer 8

ssRNA (+), enveloped

Question 9

Genetic material, capsid shape, tropism and sx of Ebola:

Answer 9

ssRNA (-), helical, Macrophages, hemorrhagic fever