Heme Metabolism Flashcards
1
Q
Microcytic, hypochromic anemia due to slow heme production.
-Ex: can be caused by isoniazid for TB
A
B6 deficiency
2
Q
o Hepatic uroporphyrinogen decarboxylase (URO-D)
o Most common porphyria
o Bullous dermatosis, scarring, hyperpigmentation, hypertrichosis (hair growth)
Bullous lesions in sun exposed regions w/o neurovisceral Sx’s
o Increased iron stores may be due to down-regulation of hepcidin
o TQ: Associated w/Hepatitis C
o Always screen for HFE C282Y homozygosity/other Fe overload forms
A
Porphyria Cutanea Tarda
3
Q
Elevated indirect (unconjugated) bilirubin indicates?
A
Hemolysis
4
Q
Elevated direct (conjugated) bilirubin indicates?
A
Obstruction downstream of liver
