Iron deficiency anemia

Question 1

what is MCC of anemia worldwide?

Answer 1

iron deficiency anemia

Question 2

MCC of iron deficiency anemia

Answer 2

bleeding

Question 3

iron deficiency anemia results from inadequate supply of iron for synthesis of ___.

Answer 3

Hgb

Question 4

3 causes of iron deficiency anemia

Answer 4

1. chronic blood loss: excessive menstruation, OCCULT
2. dietary deficiency/ inc. requirements of iron: pregnancy, rapid growth, breastfed infants
3. chronic aspirin or NSAID use

Question 5

epidemiology of iron deficiency anemia

Answer 5

diet
decreased absorption
blood loss
birth to age 2, adolescents
W>M
Pregnancy

Question 6

explain how iron deficiency starts and ends in being microcytic

Answer 6

first, there is a deletion of iron stores with out anemia. then theres is anemia with normal RBC size. then it turns into anemia with reduced blood cell size (low MCV)

Question 7

is iron deficiency anemia (macro/microcytic) and (hypo/hyperchromic)

Answer 7

MICROCYTIC

HYPOCHROMIC

Question 8

Signs and symptoms of iron deficiency anemia

Answer 8

often asymptomatic, but if present:
Pagophagia (ice craving), PICA
angular chelitis, koilonychia, glossitis
pale palpebral conjunctiva, hypotension
fatigue, palpitations, syncope, bruising, pallor, tachy, anorexia, irritable

Question 9

what are symptoms in Plummer-vinson syndrome?

Answer 9

dysphagia, esophageal webs, atrophic glossitis, Fe deficiency

Question 10

what will labs show in someone with iron deficiency anemia

Answer 10

LOW FERRATIN
LOW SERUM IRON
LOW TRANSFERRIN SATURATION
LOW RBCs, Hgb, Hct, MCV

HIGH TIBC

Question 11

Peripheral blood smear in a patient with iron deficiency anemia will show

Answer 11

anisocytosis, poikilocytosis

decreased reticulocyte count

Question 12

what is gold standard diagnostic for patient with iron deficiency anemia

Answer 12

bone marrow biopsy- look for evidence of iron stores

Question 13

treatment of iron deficiency anemia

Answer 13

iron replacement for 4-6 months- FeSO4 325 mg TID PO

Question 14

what should you avoid dosing iron with

Answer 14

antacids

Question 15

what increases iron absorption

Answer 15

vitamin C

Question 16

main side effect of iron supplementation

Answer 16

constipation

Question 17

when should you use parental iron

Answer 17

if pt can’t tolerate pO iron, if pt has continuous bleeding, or if pt has GI disease