Factor V Leiden Mutation Flashcards
most common cause of inherited thrombophlia
Factor V Leiden Mutation
is Factor V Leiden Mutation autosomal dominant or recessive
autosomal dominant
what does activated C protein resistance lead to?
hypercoaguble state because the Factor V Leiden Mutation renders factor V and Va partially
epidemiology of Factor V Leiden Mutation
present in 3-7% Europeans and white north americans
factor V is one of the essential clotting factors in the coagulation cascade. what does it do?
it allows factor X to stimulate conversion of prothrombin to thrombin which is able to cleave fibrinogen to fibrin and allows it to clot
acticated protein c is a natural ____.
anticoagulant
how does activated protein c work?
it limits the extent of clotting by destroying factor V and reducing further thrombin formation
Factor V Leiden Mutation cannot be activated by protein c, this leads to
hyper-coagulable state
clinical manifestation of Factor V Leiden Mutation
usually diagnosed following thrombophilia screening due to VTE in pt or close relative
may also be detected inwork up for patients with many miscarriages
work up formay also be detected in
genetic testing- PCR for Factor V Leiden Mutation IS 99% ACCURATE
treatment for Factor V Leiden Mutation
usually only when blood clot develops
anticoagulant is dOC
meds: warfarin, heparin, fondaparinux
complications of Factor V Leiden Mutation
DVT, PE, MI, STROKE, arterial thrombosis
monitoring for Factor V Leiden Mutation
monitor with PT/INR
medical ID bracelet
