Investigations Flashcards
Antibodies associated with autoimmune hepatitis
IgG
Antibodies associated with primary billiary cirrhosis/cholangitis
IgM
Antibodies associated with coeliac disease
Anti-tissue transglutaminase antibodies (IgA), IgA anti-endomysial antibody (IgA), anti-deamidated gliadin peptides (IgG)
Antibodies associated with Goodpasture’s syndrome
Anti-glomerular basement membrane antibodies against type 4 collagen found within glomerular and alveolar basement membranes
Antibodies associated with Granulomatosis with polyangiitis (Wegener’s)
cANCA (Cytoplasmic anti-neutrophil cytoplasmic antibodies)
Antibodies associated with eosinophilia granulomatosis with polyangitis (Churg-Strauss )
pANCA +ve and have raised IgE levels
Peri-nuclear anti-neutrophil cytoplasmic antibodies
Antibodies associated with SLE
Anti-dsDNA, Anti-sm, ANA
(Antinuclear antibody, double-stranded DNA and anti-smith antibody are more specific)
For drug induced SLE: Anti histone
Antibodies associated with RA
Rheumatoid factor, anti Anti-Cyclic Citrullinated Peptide (anti-CCP) is more specific
Antibodies associated with Sjogren’s Syndrome
Anti-Ro, Anti-La
RF,ANA
haemophilia A
APTT is elevated with a normal INR, normal FBC, bleeding time and platelet count
Viral hepatitis
elevated INR
. Viral hepatitis may result in liver impairment. Liver impairment leads to reduced production of vitamin K, essential for the synthesis of some clotting factors (factors II, VII, IX and X). INR is prolonged when there is a deficiency of one or more of these clotting factors.
Key abnormal blood test in pagets disease
raised ALP
Antibodies associated with autoimmune hepatitis
anti smooth muscle antibodies IgG
Antibodies associated with primary biliary cirrhosis
Antimitochondrial IgM
ANA
SLE
Sjogren’s syndrome
diffuse cutaneous systemic sclerosis
limited cutaneous systemic sclerosis
