H & S Flashcards
Beauchamp and Childress developed the Four Principles of Biomedical Ethics in 1978. They identified four principles that must be considered and balanced against each other in order to provide ethical healthcare.
Autonomy- patient should be provided with enough information and support to make their own informed decision about their healthcare, and this decision should be respected.
beneficence- care should always be “doing good”, i.e. acting in the patient’s best interests
non-maleficence - care should not cause a patient harm.
Justice- relates to the fair and equal distribution and access to healthcare resources.
Health education
give people knowledge & skill to change potentially health damaging behaviours, e.g. advice from health professionals, mass media campaigns.
Health protection
legislation to protect public health, e.g. not smoking inside, pollution, seat belts.
Give approaches to health promotion
- Health persuasion e.g. campaigns, posters
- Legislative action e.g. smoking bans in public places, pollution regulation, car seat belts, fluoride in water
- Personal counselling e.g. opportunistic prevention in one-to-one setting, community settings with youth or community workers
- Community development e.g. food cooperatives
Validity
assuming the premises are true, does the conclusion follow logically?
Sound
are the premises of the argument actually true?
BASIC REPRODUCTIVE NUMBER (R0) =
avg no. of individuals directly infected by an infectious case, in a totally susceptible population.
Determined by virulence factors, therefore specific to microorganism + population. Proportionate to:
- Length of time infectious case remains
- Number of contacts a case has with susceptible hosts, per unit time.
- Chance of transmission during one of these encounters (depends on pathogen’s innate virulence)
Doesn’t fluctuate in short term, not affected by vaccination, is a property of infectious agent. Can differ for same organism in different populations.
EFFECTIVE REPRODUCTIVE NUMBER (R or RE) =
is the average number of secondary infections produced by a typical infective agent, if this number is greater than 1 then it is impossible to eradicate an infection. Since for every one eradicated a new one will appear.
Usually smaller than R0, and reflects impact of control measures and <100% susceptibility in a population.
R = R0 x S
Requirements for eradication of a disease
- No other reservoirs of infectious agent (animals/environment)
- Scientific and political prioritisation of specific agent has to exist (money + time more available) - result of infection being serious and common
- Examples of eradicated diseases - polio and smallpox
Herd Immunity =
large portion of a community (the herd) becomes immune to a disease (due to vaccination usually) such that it is difficult for the disease to spread (because there are not as many people who can be infected)
The formula for calculating the herd-immunity threshold is 1–1/R0
Managing side effects of vaccines:
○ Prophylactic medication (i.e. paracetamol and ibuprofen)
○ Space out vaccines
○ Yellow cad system
○ Monitoring post vaccine
○ Ability to access healthcare if experience side effects
○ Make sure those with underlying conditions have advice (i.e. von Willerband Factor deficiency should take a dose of Transexamic Acid before the COVID vaccine)
Primary disease prevention
prevent onset of disease; hard for some conditions as hard to know when onset of disease is (could be before symptoms come on ) = address cause of causes, e.g. cause of obesity that causes DM
Different types:
Universal (whole population)
Selective (risk group)
Individual (identify high risk individuals, e.g. genetic mutations)
Secondary disease prevention
cure / identify disease earlier, e.g. screening
Definition of screening
Application of a test to identify individuals at sufficient risk of a disorder to warrant investigation or direct preventative action, amongst persons who have not sought medical attention on account of symptoms
Screening test requirements
- The condition being screened for should be an important health problem
- The natural history of the condition should be well understood
- There should be a detectable early stage (pre-clinical and/or risk factor, long enough so there is chance of detection)
- Treatment at an early stage should be of more benefit than at a later stage
- A suitable test should be devised for the early stage
- The test should be acceptable
- Intervals for repeating the test should be determined
- Adequate health service provision should be made for the extra clinical workload resulting from screening
- The risks, both physical and psychological, should be less than the benefits
- The costs should be balanced against the benefits
Tertiary disease prevention
manage disease
Breast screening
50 - 70
Mammography
Routine Repeat after 3 years
Bowel screening
60 to 74 sent FIT test every 2 years
term used to describe the phenomenon that only a proportion of symptoms experienced by patients lead to a consultation
‘Symptoms iceberg’
70% of symptoms are never reported.
Triggers for seeking healthcare:
Interference with work / hobbies / house work
Interference with social relations
Interpersonal crisis = death of relative / friend, divorce, loss of child etc.
Putting a time limit on symptoms = will seek help if not resolved by certain time
Sanctioning = told to be someone else
Black Report conclusions on inequalities in health care:
Statistical artefact (not genuine) Natural selection (less well become poorer) Materialistic exploitation of the lower socioeconomic classes Cultural / behavioral explanations
determinants of health inequalities
- Healthy people move up the classes
- Poverty causes ill health
- Life style differences
- Social selection
Barriers influencing access to care
provision/availabilty of services cultural/family attitudes previous bad experience logistics risk perception
Exercise guidelines
150 minutes of moderate intensity exercise OR 75 minutes of vigorous intensity per week = minimum of 30 mins each time
2x muscle strengthening activity per week
Limited time sat sedentary
Balance & co-ordination twice a week in elderly
National Service Frameworks:
role
“Policies set by NHS to define care standards for major diseases (Cancer, CHD, COPD, DM etc.) or for specific patient groups (elderly, palliative care)”
1) Set formal quality requirements, based on best evidence for / against treatments and services
2) Offer strategies / support to help organisations attain these
Who is involved in National service frameworks
Department of Health = create the strategy, after identifying need for one
Strategic Health Authority = implement + manage it
Consultation with patients, carers, public, charities, healthcare professionals and industry
Epidemic:
Occurrence in a community / region of cases of an illness / health-related behaviour clearly in excess of normally expected
Endemic:
Persistent, usual, or expected level of disease in a given population
Pandemic:
Epidemic over a very wide area, crossing international boundaries
Adverse event
“An unintended event resulting from clinical care and causing patient harm (physical or psychological)”
very preventable and common
eg prescribing error
Near miss:
events or omissions arising during clinical care but not developing far enough to cause injury to a patient i.e. not an adverse event.
Never event:
serious patients safety incidents that should not occur if the available preventative measures have been implemented
e.g. wrong site surgery / retained instrument in surgery / wrong chemotherapy admin route / inpatient suicide using collapsible rails / postpartum haemorrhage = maternal death after elective C-section / IV administration of concentrated KCl
For successful negligence claim relating to treatment/diagnosis, 3 things need to be proven
Causation
Duty: a duty of care existed between doctor and patient
Breach: the doctor’s practice fellow below the standard of care expected
Bolam v Bolitho
Bolam Test is used to see if the doctor’s actions are supported by a responsible body of medical opinion.
If they are not, then there has been a breach in the duty of care.
If they are, then the Bolitho Test is applied.
Bolitho Test is used to scrutinise if the actions undertaken by the doctor and supported by the medical opinion are logical.
If they are not, then there has been a breach in the duty of care.
If they are, then the duty of care has not been breached.
Most common errors
Prescribing = wrong dose, drug, route of admission
Communication failure
Delay / failure in diagnosis
Obstetricians get sued the most (around 85% have been sued at some point)
Duty of Candour
- Must tell patient when something has gone wrong
- Must apologise & offer appropriate resolution
- Must explain the potential short & long-term effects
Common complaints:
- Safety issues
- Poor / insufficient information
- Ineffective clinical practice, including poor coordination of discharge
- Poor handling of complaints ie failure acknowledge validity / to apologise / jargon in response / not explained what done
- Lack of dignity / respect / poor attitudes of staff
- Failure to follow consent procedure
- Poor environment including poor hygiene
What is standardised mortality ratio (SMR)?
Ratio between observed number of deaths in a study population to the number of expected deaths
Calman-Hine Report (1995)
Concluded unacceptable variation in quality of treatment between hospitals = services were disjointed & outcomes were poor
Highlighted need for strategic clinical cancer networks
- So would be better to centralize treatment to improve quality, with primary care at the center of this
- Should ensure all patient have equal access to care
- Public & professionals educated on recognizing early signs
- Services should be patient centered, given clear info on treatment options & outcomes
- Cancer registration & monitoring of outcomes is essential
- Psychosocial needs of carers & patient recognized
Cancer Networks (34 in total) – 3 levels of care:
Primary Care - prevention & early diagnosis Cancer Unit (1 per 250,000) - treat common cancer, make diagnosis (non-complex chemo & surgery) Cancer Center (1 per million) - treat rare cancers, radiotherapy, complex chemotherapy & surgery
Role of strategic cancer networks/what they do:
development of strategic plans for delivering better care
bring together those who use, provide and commission services to make improvements in outcomes for complex patient pathways using an integrated, whole system approach
Implementation of national policies
Deliver the improvements in care
Provide a channel for communication between groups across the network
Provide resources for audits and research
benefits of strategic cancer networks
Accurate studies on epidemiology of different cancers- useful for guiding future research
Commision care in a way to reduce inequalities in care throughout the SCN region , Reduces postcode lottery
Reduces incidence of cancer - through better screening programs and greater focus of cancer in primary care
Maximise survival of CA patients
Enhance quality of life of patients and families
Improve the patient experience of cancer services
Concentraing specialist care in cancer centres
pros- better case management of less common conditions
cons- increased geographical inequalities in cancer service provision, barriers to accessing care ( cost of travel, effort)
National Cancer Research Network:
Established in 2001
They support and promotes recruitment of patients into cancer trials and improves the speed of research into clinical practice to ensure patients receiving best possible and up to date care
Closely matched to cancer networks to improve patient numbers etc.
National Cancer Research Institute:
created to develop common plans for cancer research and to avoid unnecessary duplication of studies / effort
Established in 2001
Roles:
Invest in facilities + resources for research
Maintain cancer research database and analyze new research
Develop research initiatives
Coordinate clinical trials for new drugs
The audit cycle:
- Identify the issue
- Obtain or define standards Find the guideline which you are going to compare your data to
- Collect data/measure current performance
- Compare performance with standards and identify causes of non achievement
- Implement change
- Re-audit
Why audit?
Improves patient care by identifying shortcomings
Provides opportunities for clinical education.
Assess progress against national standards.guidelines are based on best evidence so important that they are closely followed on the front line in hospital
Financial benefits. Can check Services running efficiently and resources used appropriately
Fulfils contractual obligation
Encourages teamwork
Limitations audit
The only thing you are comparing to is current best practice May not always help Costs time, money and resources If it doesn't change anything, resources have been wasted ‘Snapshot’ nature of information Lack of generalisability Accuracy of data collection Size of results examined
Research ethics principles - Nuremberg Code
- Voluntary consent is required
- Should yield results beneficial to society that cannot be acquired by other means
- Based on animal experimentation and a knowledge of natural history of the disease
- Avoid all unnecessary physical and mental suffering
- Should not be performed if there is a reason to believe the intervention is harmful
- Risk should not exceed the benefits
- Preparations and facilities should be provided to protect subjects and injury, disability, or death
- Should be conducted by scientifically qualified people
- Subjects should be able to leave whenever they wish
- Scientists in charge must be prepared to end the experiment is there is evidence of harm (or likely to be)
Incidence:
Number of new cases over a period of time
New cases of disease within a period / number initially free of disease
Prevalence:
Number of cases present in a population at a given time
Number of people with disease at particular point in time / total population
Changes as people die/emigrate/are cured
10 legal requirements for a post-mortem:
Sudden / unexpected death
Unknown cause of death / unnatural death (accident / suicide / suspicious)
History of violence or substance abuse, alcoholism etc.
Death may be due to a medical procedure either invasive or not
Industrial disease death
Death from negligence
Death within 24 hours of admission
Not seen by doctor for 14 days
Patient detained under MHA
Receiving war pension / industrial disability pension unless death shown to be unconnected
For consent to be valid it must me
voluntary informed and patient must have capacity
to make consent informed the patient must be provided with basic overview of their condition, likely outcome of their decision, their treatment options including a second opinion
Name three statutes that oblige physicians to disclose information without the consent of the patient.
Public Health (Control of Diseases) Act 1984 (Notifiable diseases)
Abortion Act 1967
Birth and Deaths Registration Act 1953
Road Traffic Act 1988
Human Fertilization and Embryology Act 1990
NHS Venereal Diseases Regulations 1974
Prevention of Terrorism Act 1989/terrorism act 2000
Drug trafficking act 1986
Criteria to fulfil when breaching confidentiality under a public interest defence
A risk of harm needs to be identified
Patient consent should be gained if possible
You do not need to attempt to gain consent if doing so would put you at risk of serious harm, or would prejudice the prevention, detection or prosecution of crime.
The patient should be warned that disclosure will be made
Disclosure should be made on a need-to-know basis (i.e. only to the relevant people)
The disclosures made should be kept to a minimum (i.e. only disclosing relevant information)
The information should be anonymised, if possible.
Impairment
- Temporary or permanent loss or abnormality of body structure or function
- May be functional, physiological or psychological
eg amputated leg/ muscle pain
Disability
Restriction of normal activity from impairment
Lack of ability to perform an activity in the manner/within a range considered normal
eg walking
Handicap
Limits or prevents the fulfilment of a role that is normal for that individual
eg going to shop
Human Rights acts relevant to healthcare
- Article 2 = right to life
- Article 3 = prohibition of torture (or inhuman or degrading treatment of punishment)
- Article 5 = right to liberty and security
- Article 6 = right to a fair trial
- Article 8 = right to respect for private and family life
- Article 9 = freedom of thought, conscience and religion
- Article 10 = freedom of expression
- Article 12 = right to marry and found a family
- Article 14 = prohibition of discrimination
Chance of conception
People who are concerned about their fertility should be informed that over 80% of couples in the general population will conceive within 1 year if:
- the woman is aged under 40 years and
- they do not use contraception and have regular sexual intercourse.
Of those who do not conceive in the first year, about half will do so in the second year (cumulative pregnancy rate over 90%)
aginal sexual intercourse every 2 to 3 days optimises the chance of pregnancy.
causes of infertility
○ Male/ Sperm problems (30%) ○ Ovulation problems (25%) ○ Tubal problems (15%) ○ Uterine problems (10%) ○ Unexplained (20%)
Consider unstimulated intrauterine insemination as a treatment option in the following groups as an alternative to vaginal sexual intercourse:
people who are unable to, or would find it very difficult to, have vaginal intercourse because of a clinically diagnosed physical disability or psychosexual problem who are using partner or donor sperm
people with conditions that require specific consideration in relation to methods of conception (for example, after sperm washing where the man is HIV positive)
people in same-sex relationships.
Intracytoplasmic sperm injection (ICSI)
Same as IVF but instead of allowing the insemination mixing, sperm are injected into oocytes.Indicated when quality of sperm is poor/low sperm count or when pregnancy has failed in the past
IVF criteria according to NICE if <40
In women aged under 40 years who have not conceived after 2 years of regular unprotected intercourse or 12 cycles of artificial insemination (where 6 or more are by intrauterine insemination), offer 3 full cycles of IVF, with or without ICSI. If the woman reaches the age of 40 during treatment, complete the current full cycle but do not offer further full cycles.
In women aged under 40 years any previous full IVF cycle, whether self- or NHS-funded, should count towards the total of 3 full cycles that should be offered by the NHS.
IVF criteria according to NICE if >40
In women aged 40–42 years who have not conceived after 2 years of regular unprotected intercourse or 12 cycles of artificial insemination (where 6 or more are by intrauterine insemination), offer 1 full cycle of IVF, with or without ICSI, provided the following 3 criteria are fulfilled:
- they have never previously had IVF treatment
- there is no evidence of low ovarian reserve
- there has been a discussion of the additional implications of IVF and pregnancy at this age.
CCGs may have additional criteria you need to meet before you can have IVF on the NHS, such as:
not having any children already, from both your current and any previous relationships
being a healthy weight
not smoking
falling into a certain age range (for example, some CCGs only fund treatment for women under 35)
Human Fertilization & Embryology Act 1990
Established the Human Fertilisation and Embryology Authority = statutory body that regulates and inspects all clinics in the United Kingdom providingIVF,artificial inseminationand the storage of humaneggs,spermorembryos. It also regulates human embryo research
“Women should not be provided with treatment unless account has been taken of welfare of any child who may be born as a result (including need for a father)”
2008 revision of father to supportive parenting
Ethical scenario IVF
FOR
- procreative autonomy: respect patient choices, minimalize state interference
- infertility can affect mental health
- welfare interest of future child
AGAINST
- embryos have moral status (destruction of embryos)
- harm to those conceive (OHSS, multiple, ectopics)
- Positive rights: no obligation to provide parents with means to have children
- Negative right: obligation not to interfere with peoples decision to have children
Abortion Act 1967 (amended 1990)
Must meet 1 of the following criteria:
- Pregnancy not 24+ weeks, and continuation would involve risk (of injury to physical/mental health of woman/existing kids) greater than that of termination
- Termination >24 weeks if necessary to prevent grave permanent injury (physical/mental), including saving mothers life
- Substantial risk that child, when born, would suffer serious handicap (due to physical / mental abnormalities)
Anti-Abortion (“pro-life”):
- Abortion ends life of foetus –> foetus has moral status of person –> wrong to end life of something with this moral status –>Abortion is morally wrong = justice
- Abortion is doing harm = non-maleficence
- Can lead to medical complications later in life both physical & psychological = non-maleficence
- Many couples are looking to adopt & abortion is depriving them of this option = justice
- Religious reasons
- abortions for Down’s syndrome – suggest they have a lower moral status than other children
Pro-abortion:
- Even if foetus is human, what about risk to mothers life? = non-maleficence
- Foetus isn’t alive so doesn’t have the rights of a human –> especially as most take place at a stage where foetus wont survive =non maleficence
- Banning will just encourage the use of unsafe & harmful methods = beneficence
- Women should be able to avoid the emotional harm of bearing a child by rape = non-malificence
- May be due to a contraceptive failure / mistake and pregnancy may reduce quality of life for mother and she may not be able to provide good quality of life for future child = beneficence
- Will allow women in teenage years to achieve full potential = justice
- women have right to decide what happens to their body/pregnnacy (autonomy)
Ethical scenario: Down’s syndrome screening
FOR
- allows parents to prepare and plan
- gives them an informed choice if they want to terminate
Ethical scenario: Down’s syndrome screening
AGAINST
- risk of false positive and negatives
- spontaneous abortion with diagnostic testing (1%)
- suggesting Down’s syndrome life is less important
cervical screening programme
Ages 25-49 invited every 3 years
Ages 50-64 invited every 5 years
most common sexually transmitted infection in the UK
Chlamydia
National Chlamydia Screening Programme
aims to screen every sexually active person under 25 years of age for chlamydia annually or when they change their sexual partner. Everyone that tests positive should have a re-test three months after treatment. This re-testing is to ensure they have not contracted chlamydia again
Preventing HIV transmission:
- media campaigns
- education in school
- testing HIV and counselling
- ART
- condom use, Distribution of condom for free espiecally amongst high risk places, e.g. brothels
- contraception reduces the risk man to woman by 50%.
- treat chlamydia and gonorrhea as these facilitate HIV transmission during sex.
- IVDU and needle change
- Effective post-exposure prophylaxis
- HIV mothers not breastfeeding
- Limiting number of sexual partners
most common non-viral sexually transmitted infections worldwide
Trichomonas vaginalis- a protozoan, and is a single-celled organism with flagella.
female genital mutilation (FGM)
‘all procedures that involve partial or total removal of the external female genitalia, or other injury to the female genital organs for non-medical reasons’.
Type 1
Partial or total removal of clitoris and/ prepuce (clitoridectomy)
Type 2
Removal of clitoris and labia minora (w/wo excision of labia majora)
Type 3
Narrowing of vaginal orifice creating a seal by cutting and appositioning the labia minora and/or labia majora with/ without excision of clitoris
Type 4
All other harmful procedures for non-medical purposes e.g. pricking, incising, scraping
Laws around FGM
ANY form of FGM is AGAINST the law in the UK INCLUDING REFIBULATION AFTER DELIVERY ( stitching up again) It carries a 14 year prison sentence
Law + child protection
Female Circumcision Act 1985 made it criminal to
Excise, infibulate or otherwise mutilate the whole or any part of the labia majora or labia minora or clitoris of another person
Aid, abet, counsel or procure a girl to mutilate her own genitalia
Law Updated
Female Genital Mutilation Act 2003 which added a further criminal offence
Aid, abet, counsel or procure another person who is not a UK national to mutilate a girl’s genitalia outside the UK
Most common gynae cancers
- endometrial
- ovarian
- cervical
- vulva
Complications of Domestic Abuse in obstetrics and gynaecology
higher rate of miscarriage premature birth & LBW fetal injury & death premature labour & delivery chorioamnionitis & maternal infections poor weight gain Violent pregnancies are high risk
Recommendations for domestic violence issues in obstetrics and gynaecology
Routine enquiry.
A named midwife should be responsible for and provide the majority of the antenatal care to a woman who has experienced domestic abuse.
Women should be given the opportunity to disclose domestic abuse in an environment in which they feel secure.
Alerts for domestic violence
Late booker/poor attender Repeat minor injury attendance Unexplained admissions Depression/anxiety/self harm Injuries of different ages (minimalisation) STD/UTI/vaginal infections Poor obstetric history Domineering partner
Risk factors of significant harm or neglect to any child who may be born or to any existing child
- Past or current circumstances that may lead to any child experiencing serious physical or psychological harm or neglect,
- Previous convictions relating to harming children
- Child protection measures taken regarding existing children, or violence or serious discord in the family environment
- Past or current circumstances that are likely to lead to an inability to care throughout childhood for any child who may be born, or that are already seriously impairing the care of any existing child of the family, for example;
a. mental or physical conditions,
b. Drug or alcohol abuse.
c. Medical history, where the medical history indicates that any child who may be born is likely to suffer from a
serious medical condition,
d. Circumstances that the centre considers likely to cause serious harm to any child mentioned above.
Epidemiology non melanoma skin cancers
BCC is the commonest form of skin cancer. It is 4-5x more common than squamous cell carcinoma (SCC).
Epidemiology Melanoma
In the UK, it accounts for approximately 4% of all new cancers.represents the fifth most common cancer.
M>F
Premalignant lesions
actinic keratosis and Bowen’s disease
Counsel patients on appropriate sun protection behaviours
SMART ways to avoid excessive sun exposure
Spend time in the shade between 11am-3pm
Make sure you never burn
Aim to cover up with a t-shirt, wide-brimmed hat and sunglasses
Remember to take extra care with children
Then use Sun Protection Factor (SPF) 30+ sunscreen
Dx Hypertension
clinic blood pressure of 140/90 mmHg or higher and
ABPM daytime average or HBPM average of 135/85 mmHg or higher.