Investigating PU/PD Flashcards
Whta is normal water intake in horse
20-30L/ day for a 500kg horse
define polydipsia in horse
> 70-100ml/kg/day
7-10% body weight
define polyuria in horse
> 50ml/kg/day (5%BWT)
Difficult to quantify!
24h urine collection impractical
List 4 physiological causes of PU/PD in horses
Excessive dietary protein
Excessive salt consumption
Drug administration
high enviornmental temp
List 3 drugs that can cause PU/PD
glucocorticoids
diuretics
a-2 agonists
List 8 pathological causes of PU/PD
Apparent Psychogenic polydipsia (APP)
PPID (Equine Cushings’ disease)
Chronic renal failure (CRF)
Hepatic insufficiency
Sepsis/endotoxaemia
Renal medullary solute washout
Diabetes Mellitus (DM)
Diabetes Insipidus (DI)
What is seen with Apparent Psychogenic Polydipsia (APP)
good BCS/ not azotaemic
Results in significant PU - often “flooded” stables
what causes Apparent Psychogenic Polydipsia (APP)
Reflection of change diet (excessive salt consumption), stabling, management, environment, meds
How to diagnose Apparent Psychogenic Polydipsia (APP)
by exclusion
how to manage Apparent Psychogenic Polydipsia (APP)
restrict salt intake
restrict water intake
Clinical signs of PPID
PU/PD
long curly coat
weight loss/ muscle wasteage
varied
How to diagnose PPID
resting ACTH
How to treat PPID
pergolide
dietary management
what is neurogenic DI
central- inadequate secretion of ADH
what is nephrogenic DI
Decreased sensitivity of epithelial cells on collecting ducts to circulating ADH