Introduction to coagulation and platelet aggregation

Question 1

What are platelets produced from?

Answer 1

Platelets are produced in the bone marrow by fragmentation of megakaryocytic

Question 2

What is the function of platelets in haemostatsis?

Answer 2

The maintenance of vascular integrity

The initial arrest of bleeding by platelet plug formation

Question 3

What is platelet adhesion?

Answer 3

a response to vascular injury, the first step during which single platelets bind through specific membrane

Question 4

State the importance of platelet adhesion

Answer 4

limits blessing following blood vessel injury by promoting platelet aggregation and clot formation.

Question 5

What is VWF, Von Willebrand Factor?

Answer 5

A blood glycoprotein involved in hemostasis.

It initiated platelet adhesion and sustains platelet aggregation.

Question 6

What binding sites do platelets attach on to the VWF?

Answer 6

GPib - IX - V complex receptor

Integrin (Beta) aIIb

Question 7

Explain Platelet activation.

Answer 7

ADP release

Thrombin

Question 8

What are the markers of platelet activation?

Answer 8

PF4
PDGF
Thromboglobulin

Question 9

What is the coagulation pathway?

Answer 9

A cascade of events that leads to secondary haemostasis

Question 10

What is the extrinsic pathway?

Answer 10

Damaged endothelial cells release tissue factor TF
This then activates Factor 7
which activates factor.
This then activates Factor 10 which activates factor 10a

Question 11

What factors are involved in the extrinsic pathway?

Answer 11

1
2
7
10

Question 12

What factors are involved in the intrinsic pathway?

Answer 12

1
2
9
10
11
12